HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: MEP50 (Q99J09)
Methylosome protein WDR77 (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77)
Gene: Wdr77

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	20951943
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 303 Mm			1 342
+	Hs
		625583 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		MEP50_HUMAN (1-342): 1.79e-85: 263: 89.77
+	Hs
		625202 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		LIS1_HUMAN (62-338): 7.73e-74: 235: 15.44
+	Hs
		515500 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		MEP50_HUMAN (1-342): 1.79e-85: 263: 89.77
+	Hs
		414806 CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24		LIS1_HUMAN (62-338): 7.73e-74: 235: 15.44
+	Hs
		625543 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		FBXW7_HUMAN (15-236): 1.86e-34: 135: 15.52
+	Hs
		415016 CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24		FBXW7_HUMAN (15-236): 1.86e-34: 135: 15.52
+	Hs
		515357 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		COPB2_HUMAN (16-210): 1.07e-20: 95.3: 15.42