HitPredict

Interactor 1: MPIP1 (P30304)
M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)
Gene: CDC25A

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22899714
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Rhodanese
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 524 Hs			1 292
+	Hs
		625158 MPIP1_HUMAN (1-524): 0: 723: 100.00		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		673388 MPIP1_HUMAN (1-524): 0: 723: 100.00		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		414767 MPIP1_HUMAN (1-524): 0: 723: 100.00		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Rn
		823140 MPIP1_RAT (1-524): 0: 673: 84.09		CDK5_RAT (1-292): 3.55e-138: 393: 99.32
+	Rn
		823142 MPIP2_RAT (30-522): 0: 564: 41.51		CDK5_RAT (1-292): 3.55e-138: 393: 99.32
+	Hs
		625159 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		673468 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		673469 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		414768 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		673470 MPIP2_HUMAN (32-522): 0: 544: 43.02		CDK16_HUMAN (1-286): 1.11e-115: 343: 57.99
+	Hs
		625160 MPIP3_HUMAN (31-523): 1.2e-156: 456: 34.46		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		673567 MPIP3_HUMAN (31-523): 1.2e-156: 456: 34.46		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		414769 MPIP3_HUMAN (31-523): 1.2e-156: 456: 34.46		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Rn
		89020 D4ADT2_RAT (31-523): 1.86e-140: 414: 30.42		CDK5_RAT (1-292): 3.55e-138: 393: 99.32
+	Mm
		509473 MPIP3_MOUSE (1-523): 2.66e-127: 380: 29.02		CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70
+	Sp
		383444 MPIP_SCHPO (195-509): 1.08e-89: 288: 26.65		CDK1_SCHPO (1-290): 7.99e-128: 367: 52.35
+	Dm
		618386 TWINE_DROME (213-508): 6.99e-89: 281: 33.22		CDK1_DROME (1-287): 4.06e-130: 373: 56.40
+	Sc
		339449 MPIP_YEAST (357-509): 7.06e-55: 195: 35.37		CDK1_YEAST (1-288): 1.39e-123: 356: 55.44