Protein: ISCS
Cysteine desulfurase IscS (EC 2.8.1.7) (NifS protein homolog) (ThiI transpersulfidase) (TusA transpersulfidase)

Gene: ISCS
Organism: Escherichia coli K-12
Interactions: 49
UniProt ID: P0A6B7

Gene Ontology (top 5):
GO:0002143 - tRNA wobble position uridine thiolation
GO:0002937 - tRNA 4-thiouridine biosynthesis
GO:0005829 - cytosol
GO:0009000 - selenocysteine lyase activity
GO:0009228 - thiamine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

489343

ISCU
Iron-sulfur cluster assembly scaffold protein IscU

4

7

Small-scale

0.908

High

489332

TUSA
Sulfur carrier protein TusA

4

1

Small-scale

0.903

High

489335

FER
2Fe-2S ferredoxin

2

1

Small-scale

0.806

High

489356

CYAY
Iron-sulfur cluster assembly protein CyaY

1

4

Small-scale

0.724

High

489360

FDHD
Sulfur carrier protein FdhD

3

0

Small-scale

0.645

High

489277

ACP
Acyl carrier protein

1

3

Small-scale

0.575

High

489331

RS9
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

489334

DLDH
Dihydrolipoyl dehydrogenase

1

2

High-throughput

0.536

High

489340

YCHF
Ribosome-binding ATPase YchF

1

2

High-throughput

0.536

High

489354

NADE
NH(3)-dependent NAD(+) synthetase

1

1

High-throughput

0.536

High

450068

PROA
Gamma-glutamyl phosphate reductase

1

0

High-throughput

0.513

High

489328

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.513

High

489333

RRAA
Regulator of ribonuclease activity A

1

0

High-throughput

0.513

High

489339

NAPC
Cytochrome c-type protein NapC

1

0

High-throughput

0.513

High

489341

HCAC
3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit

1

0

High-throughput

0.513

High

489342

GNSA
Protein GnsA

1

0

High-throughput

0.513

High

489344

YMJA
Uncharacterized protein YmjA

1

0

High-throughput

0.513

High

489346

RIMO
Ribosomal protein uS12 methylthiotransferase RimO

1

0

High-throughput

0.513

High

489348

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.513

High

489351

MURF
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

1

0

High-throughput

0.513

High

489358

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.513

High

489368

BAER
Transcriptional regulatory protein BaeR

1

0

High-throughput

0.513

High

489330

PYRE
Orotate phosphoribosyltransferase

1

0

High-throughput

0.493

High

421064

APPY
HTH-type transcriptional regulator AppY

1

1

High-throughput

0.489

High

480649

RHAR
HTH-type transcriptional activator RhaR

1

1

High-throughput

0.489

High

489363

MENE
2-succinylbenzoate--CoA ligase

1

1

High-throughput

0.489

High

489329

DNAK
Chaperone protein DnaK

1

5

High-throughput

0.484

High

489338

CISY
Citrate synthase

1

2

High-throughput

0.479

High

489345

YEBG
Uncharacterized protein YebG

1

0

High-throughput

0.458

High

489369

NPD
NAD-dependent protein deacylase

1

3

High-throughput

0.442

High

489357

YHHH
Uncharacterized protein YhhH

1

0

High-throughput

0.282

High

365940

BGAL
Beta-galactosidase

1

0

High-throughput

0.279

Low

489327

PNCC
Nicotinamide-nucleotide amidohydrolase PncC

1

0

High-throughput

0.279

Low

489336

YBEL
Uncharacterized protein YbeL

1

0

High-throughput

0.279

Low

489337

ATPD
ATP synthase subunit delta

1

0

High-throughput

0.279

Low

489349

RNK
Regulator of nucleoside diphosphate kinase

1

0

High-throughput

0.279

Low

489350

LPXB
Lipid-A-disaccharide synthase

1

0

High-throughput

0.279

Low

489352

BIOC
Malonyl-[acyl-carrier protein] O-methyltransferase

1

0

High-throughput

0.279

Low

489353

MIAA
tRNA dimethylallyltransferase

1

0

High-throughput

0.279

Low

489361

HOFQ
DNA utilization protein HofQ

1

0

High-throughput

0.279

Low

489362

RLMA
23S rRNA

1

0

High-throughput

0.279

Low

489364

SPRT
Protein SprT

1

0

High-throughput

0.279

Low

489365

YECH
Uncharacterized protein YecH

1

0

High-throughput

0.279

Low

489366

YDBH
Probable phospholipid transport protein YdbH

1

0

High-throughput

0.279

Low

489367

PROXY
Multifunctional Ser/Thr-tRNA deacylase ProXp-y

1

0

High-throughput

0.279

Low

489370

QUEC
7-cyano-7-deazaguanine synthase

1

0

High-throughput

0.279

Low

489347

MLTD
Membrane-bound lytic murein transglycosylase D

1

0

High-throughput

0.253

Low

489355

HYPD
Hydrogenase maturation factor HypD

1

0

High-throughput

0.249

Low

489359

YEDD
Uncharacterized lipoprotein YedD

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025