HitPredict

Interactor 1: MPIP2 (P30305)
M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
Gene: CDC25B

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	36931259, 15173315, 16672277
Identification Methods	cross-linking study, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 580 Hs			1 248
+	Rn
		823141 MPIP2_RAT (1-580): 0: 830: 79.66		1433E_RAT (2-246): 4.41e-146: 410: 60.41
+	Hs
		673463 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		673464 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		646656 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Mm
		673543 MPIP2_MOUSE (1-580): 0: 833: 80.90		1433B_MOUSE (1-239): 3.73e-99: 290: 68.62
+	Hs
		673452 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		673462 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		673471 MPIP2_HUMAN (1-580): 0: 823: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		673366 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		673381 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Rn
		823139 MPIP1_RAT (45-578): 0: 618: 42.59		1433E_RAT (2-246): 4.41e-146: 410: 60.41
+	Hs
		673382 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		646655 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Xl
		223343 MPIP2_XENLA (49-577): 0: 536: 35.53		O57468_XENLA (2-246): 5.73e-145: 407: 60.00
+	Hs
		673365 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		673380 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		673390 MPIP1_HUMAN (46-578): 0: 636: 44.73		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		673546 MPIP3_HUMAN (160-577): 2.99e-146: 432: 35.10		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		646657 MPIP3_HUMAN (160-577): 2.99e-146: 432: 35.10		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		673545 MPIP3_HUMAN (160-577): 2.99e-146: 432: 35.10		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62