Protein: ADH3
Alcohol dehydrogenase 3, mitochondrial (EC 1.1.1.1) (Alcohol dehydrogenase III) (ADHIII) (YADH-3)

Gene: ADH3
Organism: Saccharomyces cerevisiae S288C
Interactions: 94
UniProt ID: P07246

Gene Ontology (top 5):
GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway
GO:0004022 - alcohol dehydrogenase (NAD+) activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452615

HSP71
Heat shock protein SSA1

4

8

High-throughput

0.666

High

452607

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

17

High-throughput

0.618

High

452613

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.584

High

452677

TOM22
Mitochondrial import receptor subunit TOM22

2

2

High-throughput

0.584

High

358083

ADH1
Alcohol dehydrogenase 1

1

18

High-throughput

0.575

High

452621

HSC82
ATP-dependent molecular chaperone HSC82

2

10

High-throughput

0.571

High

452627

ACON
Aconitate hydratase, mitochondrial

2

2

High-throughput

0.571

High

452628

HSP60
Heat shock protein 60, mitochondrial

2

2

High-throughput

0.571

High

452622

HSP26
Heat shock protein 26

2

0

High-throughput

0.563

High

452625

MDHM
Malate dehydrogenase, mitochondrial

2

0

Small-scale

0.559

High

452616

HSP72
Heat shock protein SSA2

2

8

High-throughput

0.552

High

452641

RENT1
ATP-dependent helicase NAM7

1

1

High-throughput

0.536

High

452614

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.515

High

452655

YBR2
Uncharacterized RING finger protein YBR062C

1

1

High-throughput

0.515

High

452618

MITF2
Mitochondrial translation factor 2

1

0

High-throughput

0.513

High

452626

ADT2
ADP,ATP carrier protein 2

1

0

Small-scale

0.513

High

452686

SML1
Ribonucleotide reductase inhibitor protein SML1

1

0

High-throughput

0.513

High

452612

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

12

High-throughput

0.501

High

452643

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.493

High

452653

DAD2
DASH complex subunit DAD2

1

0

High-throughput

0.493

High

452669

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

0

High-throughput

0.493

High

452688

KYNU
Kynureninase

1

0

High-throughput

0.493

High

366883

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

392008

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.479

High

394010

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

452629

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

452637

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

1

High-throughput

0.479

High

452639

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

1

High-throughput

0.479

High

452640

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

452645

HOG1
Mitogen-activated protein kinase HOG1

1

1

High-throughput

0.479

High

452646

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

1

High-throughput

0.479

High

452647

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

452649

PREP
Presequence protease, mitochondrial

1

1

High-throughput

0.479

High

452650

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

452652

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.479

High

452662

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

1

High-throughput

0.479

High

452665

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

2

High-throughput

0.479

High

452674

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

3

High-throughput

0.479

High

452675

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

452676

MPS3
Spindle pole body assembly component MPS3

1

2

High-throughput

0.479

High

452679

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

452682

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

1

High-throughput

0.479

High

452690

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

361463

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.458

High

399906

COX8
Cytochrome c oxidase subunit 8, mitochondrial

1

0

High-throughput

0.458

High

439059

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

452609

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.458

High

452610

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

452619

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

452624

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

452630

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

452631

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

452632

TOM40
Mitochondrial import receptor subunit TOM40

1

0

High-throughput

0.458

High

452634

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.458

High

452635

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

0

High-throughput

0.458

High

452636

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.458

High

452644

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.458

High

452648

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

452658

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.458

High

452660

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

452661

XDJ1
DnaJ protein homolog XDJ1

1

0

High-throughput

0.458

High

452664

ZRG8
Zinc-regulated protein 8

1

0

High-throughput

0.458

High

452668

MMF1
Protein MMF1, mitochondrial

1

0

High-throughput

0.458

High

452670

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.458

High

452671

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

452673

ETFB
Probable electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

452684

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

452685

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

452620

SSB1
Ribosome-associated molecular chaperone SSB1

1

12

High-throughput

0.445

High

452623

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

452666

IMB4
Importin subunit beta-4

1

1

High-throughput

0.445

High

452667

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.445

High

452633

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

452638

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

452654

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

452657

YB8A
Putative uncharacterized protein YBR285W

1

3

Small-scale

0.437

High

452659

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

452663

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

452689

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

386518

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

394111

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

452608

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

452611

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

452672

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

452678

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

0

High-throughput

0.426

High

452681

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.426

High

452680

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

2

High-throughput

0.417

High

452642

EF2
Elongation factor 2

1

1

High-throughput

0.407

High

452683

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.407

High

452687

RRP5
rRNA biogenesis protein RRP5

1

2

High-throughput

0.407

High

452651

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

0

High-throughput

0.269

Low

452617

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.249

Low

452656

PFF1
Vacuolar membrane protease

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025