HitPredict

Interactor 1: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.928

Property	Details
Experiments	18346204, 9178760, 35384245, 36948698, 12470648
Identification Methods	affinity chromatography technology, pull down, far western blotting, protein complementation assay, two hybrid, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 217
+	Mm
		963044 UFO_MOUSE (8-894): 0: 745: 88.29		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		411613 UFO_HUMAN (1-894): 0: 780: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		665389 EPHA3_HUMAN (2-831): 0: 646: 19.34		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		674354 UFO_HUMAN (1-894): 0: 780: 100.00		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		872630 EPHA4_HUMAN (2-836): 0: 637: 19.40		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		522808 UFO_HUMAN (1-894): 0: 780: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		70553 UFO_MOUSE (8-894): 0: 745: 88.29		B2RQ57_MOUSE (4-139): 1.45e-20: 91.3: 33.33
+	Hs
		337359 EPHA3_HUMAN (2-831): 0: 646: 19.34		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		337625 EPHA4_MOUSE (2-836): 0: 636: 19.66		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		789049 EPHA4_HUMAN (2-836): 0: 637: 19.40		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		412036 EPHA3_HUMAN (2-831): 0: 646: 19.34		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		557643 EPHA5_HUMAN (2-812): 0: 622: 20.39		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		433602 EPHA3_HUMAN (2-831): 0: 646: 19.34		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522802 EPHA3_HUMAN (2-831): 0: 646: 19.34		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		412105 EPHA4_HUMAN (2-836): 0: 637: 19.40		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Mm
		763386 EPHA4_MOUSE (2-836): 0: 636: 19.66		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433662 EPHA4_HUMAN (2-836): 0: 637: 19.40		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522871 EPHA4_HUMAN (2-836): 0: 637: 19.40		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		855777 EPHA4_HUMAN (2-836): 0: 637: 19.40		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		412104 EPHA5_HUMAN (2-812): 0: 622: 20.39		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58