HitPredict

Interactor 1: MCM4 (P30665)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (Cell division control protein 54)
Gene: MCM4

Interactor 2: CDT1 (P47112)
Cell division cycle protein CDT1 (SIC1 indispensable protein 2) (Topoisomerase-A hypersensitive protein 11)
Gene: TAH11

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

The method score is based on:

Property	Details
Experiments	19896182, 22250202, 16824194, 28643783, 31385807, 22045335
Identification Methods	biochemical, affinity chromatography technology, pull down
Interaction Type	association, physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	CDT1_C~MCM, CDT1_C~MCM_lid, CDT1_C~MCM_OB
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0003688 - DNA replication origin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005656 - nuclear pre-replicative complex and 2 others more... GO:0005737 - cytoplasm GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	933
Sc

1	604

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024