Interactor 1: MCM4 (P30665)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (Cell division control protein 54)
Gene: MCM4

Interactor 2: CDC45 (Q08032)
Cell division control protein 45
Gene: CDC45

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 24805245, 17018296, 28869037, 25313033, 25659432, 28510759, 28373564, 32804080, 21362622, 25342810, 24307213, 26255844, 26686640, 27397685, 25870112, 26250113, 30595439, 32415104, 31728581, 32585006 and 6 others

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Identification Methods anti tag coimmunoprecipitation, affinity chromatography technology, pull down, biochemical
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDC45~MCM_lid, CDC45~MCM_N, CDC45~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0005634 - nucleus
GO:0006268 - DNA unwinding involved in DNA replication
and 5 others

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Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 933
Sc

1 650
+ Hs
+ Sc
+ Sc
+ Sc
+ Hs
+ Dm
+ Hs
+ Hs
+ Sp
+ Hs
+ Sp
+ Dm
+ Dm
+ Dm
+ Sc
+ Sp

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Last updated: 15 Jul 2024