HitPredict

Interactor 1: VGLL3 (A8MV65)
Transcription cofactor vestigial-like protein 3 (Vgl-3)
Gene: VGLL3

Interactor 2: TEAD4 (Q15561)
Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)
Gene: TEAD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Vg_Tdu~YBD
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 434
+	Hs
		67948 VGLL3_HUMAN (1-326): 4.21e-133: 383: 100.00		TEAD1_HUMAN (8-434): 0: 733: 74.54
+	Hs
		67994 VGLL3_HUMAN (1-326): 4.21e-133: 383: 100.00		TEAD3_HUMAN (21-434): 0: 691: 70.82
+	Hs
		67962 VGLL3_HUMAN (1-326): 4.21e-133: 383: 100.00		TEAD2_HUMAN (40-434): 0: 648: 65.93
+	Mm
		1143753 VGLL1_MOUSE (73-262): 9.83e-57: 187: 22.87		TEAD4_MOUSE (8-434): 0: 770: 93.68
+	Mm
		671380 VGLL2_MOUSE (1-266): 5.2e-67: 214: 32.86		TEAD1_MOUSE (8-434): 0: 734: 74.77
+	Hs
		1075216 VGLL1_HUMAN (75-241): 1.8e-43: 152: 31.61		TEAD4_HUMAN (1-434): 0: 784: 100.00
+	Hs
		1237699 VGLL2_HUMAN (1-266): 7.49e-72: 227: 34.74		TEAD3_HUMAN (21-434): 0: 691: 70.82
+	Hs
		658554 VGLL1_HUMAN (75-241): 1.8e-43: 152: 31.61		TEAD1_HUMAN (8-434): 0: 733: 74.54
+	Hs
		1304846 VGLL1_HUMAN (75-241): 1.8e-43: 152: 31.61		TEAD3_HUMAN (21-434): 0: 691: 70.82
+	Hs
		1075247 VGLL1_HUMAN (75-241): 1.8e-43: 152: 31.61		TEAD2_HUMAN (40-434): 0: 648: 65.93
+	Dm
		671390 VG_DROME (81-191): 2.05e-26: 110: 28.83		SCAL_DROME (6-434): 0: 618: 58.58