Protein: SOX2
Transcription factor SOX-2

Gene: SOX2
Organism: Mus musculus
Interactions: 129
UniProt ID: P48432

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

629202

PO5F1
POU domain, class 5, transcription factor 1

7

20

Small-scale

0.963

High

872957

SOX2
Transcription factor SOX-2

2

19

Small-scale

0.754

High

873015

NANOG
Homeobox protein NANOG

4

20

Small-scale

0.694

High

148663

HDAC1
Histone deacetylase 1

4

20

Small-scale

0.694

High

873021

SALL4
Sal-like protein 4

3

20

Small-scale

0.664

High

872976

EYA1
Protein phosphatase EYA1

2

13

Small-scale

0.624

High

873001

SIX1
Homeobox protein SIX1

2

20

Small-scale

0.624

High

872991

SIN3A
Paired amphipathic helix protein Sin3a

2

8

Small-scale

0.621

High

236723

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

19

High-throughput

0.618

High

872979

CTNB1
Catenin beta-1

1

20

Small-scale

0.618

High

872977

TYY1
Transcriptional repressor protein YY1

2

13

Small-scale

0.595

High

872997

ERR2
Steroid hormone receptor ERR2

2

20

Small-scale

0.595

High

873009

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

20

Small-scale

0.594

High

872969

HDAC2
Histone deacetylase 2

2

20

Small-scale

0.588

High

873003

TFE3
Transcription factor E3

2

16

High-throughput

0.584

High

873024

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

2

10

Small-scale

0.584

High

873035

Q921K2
Poly [ADP-ribose] polymerase

2

20

Small-scale

0.584

High

872974

CBX1
Chromobox protein homolog 1

1

16

High-throughput

0.561

High

872999

CBX5
Chromobox protein homolog 5

1

16

High-throughput

0.561

High

873055

XPO4
Exportin-4

1

11

Small-scale

0.561

High

873057

Q9QX99
T-cell leukemia, homeobox 1

1

20

Small-scale

0.561

High

204336

ALX4
Homeobox protein aristaless-like 4

1

20

High-throughput

0.541

High

872965

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.541

High

872973

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.541

High

873053

Q9DCC5
Cbx3 protein

1

16

High-throughput

0.512

High

728511

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.501

High

750521

STF1
Steroidogenic factor 1

1

19

Small-scale

0.501

High

872967

UBC9
SUMO-conjugating enzyme UBC9

1

9

Small-scale

0.501

High

872983

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.501

High

873004

DLX1
Homeobox protein DLX-1

1

20

Small-scale

0.501

High

58987

CUL4B
Cullin-4B

1

14

Small-scale

0.479

High

59999

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

205514

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

18

High-throughput

0.479

High

312605

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

14

High-throughput

0.479

High

575057

LMNB1
Lamin-B1

1

18

High-throughput

0.479

High

576856

RLA0
Large ribosomal subunit protein uL10

1

6

High-throughput

0.479

High

628485

VIME
Vimentin

1

8

High-throughput

0.479

High

659097

XRCC6
X-ray repair cross-complementing protein 6

1

10

High-throughput

0.479

High

662902

PCGF2
Polycomb group RING finger protein 2

1

20

High-throughput

0.479

High

773403

RFC1
Replication factor C subunit 1

1

14

High-throughput

0.479

High

846708

MSH2
DNA mismatch repair protein Msh2

1

3

High-throughput

0.479

High

872958

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

4

High-throughput

0.479

High

872959

MSH6
DNA mismatch repair protein Msh6

1

7

High-throughput

0.479

High

872961

RUVB1
RuvB-like 1

1

7

High-throughput

0.479

High

872962

MGN
Protein mago nashi homolog

1

3

High-throughput

0.479

High

872963

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

872964

H4
Histone H4

1

8

High-throughput

0.479

High

872966

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

872970

TBX3
T-box transcription factor TBX3

1

16

High-throughput

0.479

High

872971

ELAV1
ELAV-like protein 1

1

3

High-throughput

0.479

High

872972

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

10

High-throughput

0.479

High

872975

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

872978

CREB1
Cyclic AMP-responsive element-binding protein 1

1

7

High-throughput

0.479

High

872981

CUL4A
Cullin-4A

1

14

Small-scale

0.479

High

872982

Q3TIX6
Far upstream element

1

20

High-throughput

0.479

High

872984

FUBP2
Far upstream element-binding protein 2

1

20

High-throughput

0.479

High

872985

Q3U0X6
Zinc finger protein 217

1

5

High-throughput

0.479

High

872986

DDB1
DNA damage-binding protein 1

1

6

Small-scale

0.479

High

872987

KIF22
Kinesin-like protein KIF22

1

2

High-throughput

0.479

High

872988

DDX17
Probable ATP-dependent RNA helicase DDX17

1

12

High-throughput

0.479

High

872990

Q5SUH6
Clathrin interactor 1

1

6

High-throughput

0.479

High

872992

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

12

High-throughput

0.479

High

872993

RBBP4
Histone-binding protein RBBP4

1

20

High-throughput

0.479

High

872994

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

872995

LAP2B
Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma

1

6

High-throughput

0.479

High

872996

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

8

High-throughput

0.479

High

872998

HIRA
Protein HIRA

1

20

High-throughput

0.479

High

873000

RBM38
RNA-binding protein 38

1

11

High-throughput

0.479

High

873002

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.479

High

873005

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

High-throughput

0.479

High

873007

Q6P5E3
Sal-like protein 1

1

17

High-throughput

0.479

High

873008

SRSF1
Serine/arginine-rich splicing factor 1

1

16

High-throughput

0.479

High

873010

NUP98
Nuclear pore complex protein Nup98-Nup96

1

4

High-throughput

0.479

High

873013

UBN2
Ubinuclein-2

1

14

High-throughput

0.479

High

873014

KDM5B
Lysine-specific demethylase 5B

1

6

High-throughput

0.479

High

873016

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

9

Small-scale

0.479

High

873017

ARI5B
AT-rich interactive domain-containing protein 5B

1

20

High-throughput

0.479

High

873018

RFOX2
RNA binding protein fox-1 homolog 2

1

12

High-throughput

0.479

High

873019

KAT6B
Histone acetyltransferase KAT6B

1

20

High-throughput

0.479

High

873020

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

12

High-throughput

0.479

High

873022

TREF1
Transcriptional-regulating factor 1

1

20

High-throughput

0.479

High

873023

RCOR2
REST corepressor 2

1

20

Small-scale

0.479

High

873025

MATR3
Matrin-3

1

15

High-throughput

0.479

High

873026

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

18

High-throughput

0.479

High

873027

RFC3
Replication factor C subunit 3

1

11

High-throughput

0.479

High

873028

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

873029

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

20

High-throughput

0.479

High

873030

P66B
Transcriptional repressor p66-beta

1

14

High-throughput

0.479

High

873031

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

11

High-throughput

0.479

High

873032

FUBP1
Far upstream element-binding protein 1

1

20

High-throughput

0.479

High

873033

SP16H
FACT complex subunit SPT16

1

7

High-throughput

0.479

High

873034

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

873036

GLYR1
Cytokine-like nuclear factor N-PAC

1

12

High-throughput

0.479

High

873039

PRP19
Pre-mRNA-processing factor 19

1

20

High-throughput

0.479

High

873041

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

3

High-throughput

0.479

High

873042

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.479

High

873043

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

873044

SMC1A
Structural maintenance of chromosomes protein 1A

1

7

High-throughput

0.479

High

873045

SMC3
Structural maintenance of chromosomes protein 3

1

6

High-throughput

0.479

High

873046

RBM8A
RNA-binding protein 8A

1

11

High-throughput

0.479

High

873047

RL11
Large ribosomal subunit protein uL5

1

4

High-throughput

0.479

High

873049

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

6

High-throughput

0.479

High

873050

ING5
Inhibitor of growth protein 5

1

9

High-throughput

0.479

High

873051

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

9

Small-scale

0.479

High

873052

AKAP8
A-kinase anchor protein 8

1

6

High-throughput

0.479

High

873054

RBP2
E3 SUMO-protein ligase RanBP2

1

12

High-throughput

0.479

High

873056

DAZP1
DAZ-associated protein 1

1

12

High-throughput

0.479

High

873058

TFEB
Transcription factor EB

1

8

High-throughput

0.479

High

873059

RUVB2
RuvB-like 2

1

7

High-throughput

0.479

High

873060

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

873061

ILF3
Interleukin enhancer-binding factor 3

1

20

High-throughput

0.479

High

873062

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

14

High-throughput

0.479

High

873063

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

15

High-throughput

0.479

High

872960

RD23B
UV excision repair protein RAD23 homolog B

1

4

Small-scale

0.445

High

86337

B9EKJ1
Spectrin alpha chain, non-erythrocytic 1

1

11

High-throughput

0.437

High

426886

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.437

High

627458

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.437

High

872968

TBB4B
Tubulin beta-4B chain

1

3

High-throughput

0.437

High

872980

RCN1
Reticulocalbin-1

1

1

High-throughput

0.437

High

872989

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.437

High

873006

NOP58
Nucleolar protein 58

1

7

High-throughput

0.437

High

873011

DCAF5
DDB1- and CUL4-associated factor 5

1

20

Small-scale

0.437

High

873012

PUM2
Pumilio homolog 2

1

1

High-throughput

0.437

High

873037

ATD3A
ATPase family AAA domain-containing protein 3A

1

7

High-throughput

0.437

High

873038

Q99JL6
Ribosomal protein

1

6

High-throughput

0.437

High

873048

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

6

High-throughput

0.437

High

540215

FINC
Fibronectin

1

0

High-throughput

0.249

Low

873040

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025