HitPredict

Interactor 1: DNJA1 (P31689)
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
Gene: DNAJA1

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DnaJ~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 397 Hs			1 947
+	Hs
		1290474 DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93		M3K14_HUMAN (1-947): 0: 799: 100.00
+	Rn
		871239 DNJA1_RAT (1-397): 2.91e-170: 483: 99.50		AAPK1_RAT (374-909): 5.75e-123: 386: 17.30
+	Hs
		568560 DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00		KAPCA_HUMAN (361-691): 1.53e-122: 378: 20.46
+	Dm
		1213393 Q9VFV9_DROME (1-397): 1.49e-137: 400: 58.77		AKT1_DROME (148-719): 1.12e-135: 421: 16.83
+	Sc
		520583 MAS5_YEAST (1-396): 8.35e-140: 406: 45.37		YPK1_YEAST (103-694): 6.52e-127: 401: 18.84
+	Hs
		681419 DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Sc
		419811 MAS5_YEAST (1-396): 8.35e-140: 406: 45.37		SNF1_YEAST (396-846): 2.96e-117: 374: 18.13
+	At
		187511 DNAJ3_ARATH (2-396): 4.99e-130: 382: 48.67		CIPKB_ARATH (392-755): 3.47e-128: 395: 18.72
+	Hs
		636252 DNJB1_HUMAN (5-347): 8.67e-117: 345: 32.59		AKT1_HUMAN (286-713): 3.76e-131: 405: 19.33
+	Hs
		681426 DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		681575 DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	Sc
		618312 MAS5_YEAST (1-396): 8.35e-140: 406: 45.37		STE11_YEAST (452-647): 9.17e-21: 100: 32.65
+	Hs
		1306391 DNJB4_HUMAN (5-349): 1.73e-125: 367: 32.77		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	Hs
		1028418 DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Hs
		1290477 DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14
+	Hs
		636404 DNJB1_HUMAN (5-347): 8.67e-117: 345: 32.59		M3K3_HUMAN (373-612): 7.37e-23: 106: 32.14