Protein: PSA2
Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) (Proteasome subunit alpha-2) (alpha-2)

Gene: PSA2, PSMA2
Organism: Homo sapiens
Interactions: 201
UniProt ID: P25787

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0000932 - P-body
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

681102

PSA4
Proteasome subunit alpha type-4

14

20

Small-scale

0.986

High

681139

PSA6
Proteasome subunit alpha type-6

17

19

Small-scale

0.986

High

680769

PSA1
Proteasome subunit alpha type-1

15

18

Small-scale

0.985

High

165261

PSA7
Proteasome subunit alpha type-7

7

18

Small-scale

0.974

High

681217

PSB7
Proteasome subunit beta type-7

9

20

Small-scale

0.974

High

681101

PSA3
Proteasome subunit alpha type-3

8

20

Small-scale

0.973

High

681125

PSB2
Proteasome subunit beta type-2

8

20

Small-scale

0.972

High

681108

PSB4
Proteasome subunit beta type-4

8

20

Small-scale

0.970

High

681110

PSB5
Proteasome subunit beta type-5

8

20

Small-scale

0.966

High

681106

PSB9
Proteasome subunit beta type-9

7

20

Small-scale

0.963

High

633597

PSB1
Proteasome subunit beta type-1

6

20

Small-scale

0.955

High

681124

PSB3
Proteasome subunit beta type-3

6

19

Small-scale

0.955

High

681107

PSA5
Proteasome subunit alpha type-5

6

19

Small-scale

0.950

High

681105

PSB8
Proteasome subunit beta type-8

6

20

Small-scale

0.935

High

681109

PSB6
Proteasome subunit beta type-6

5

20

Small-scale

0.934

High

681152

PSME1
Proteasome activator complex subunit 1

5

18

Small-scale

0.922

High

681116

PSB10
Proteasome subunit beta type-10

5

20

Small-scale

0.918

High

681143

PRS4
26S proteasome regulatory subunit 4

5

20

Small-scale

0.915

High

681224

PSMG3
Proteasome assembly chaperone 3

4

5

Small-scale

0.908

High

681144

PRS8
26S proteasome regulatory subunit 8

4

20

Small-scale

0.902

High

127880

PSD11
26S proteasome non-ATPase regulatory subunit 11

4

20

Small-scale

0.895

High

337443

PSMG1
Proteasome assembly chaperone 1

4

5

Small-scale

0.895

High

681145

PRS10
26S proteasome regulatory subunit 10B

4

20

Small-scale

0.895

High

681165

PSME4
Proteasome activator complex subunit 4

4

8

Small-scale

0.895

High

128149

PSD12
26S proteasome non-ATPase regulatory subunit 12

3

20

Small-scale

0.861

High

610228

PRS6A
26S proteasome regulatory subunit 6A

3

20

Small-scale

0.861

High

681206

PSMF1
Proteasome inhibitor PI31 subunit

3

6

Small-scale

0.861

High

681211

PSMG2
Proteasome assembly chaperone 2

3

8

Small-scale

0.861

High

681238

PSME2
Proteasome activator complex subunit 2

3

18

Small-scale

0.861

High

681100

PSA2
Proteasome subunit alpha type-2

3

19

Small-scale

0.853

High

681115

PRS7
26S proteasome regulatory subunit 7

3

20

Small-scale

0.847

High

681118

PRS6B
26S proteasome regulatory subunit 6B

3

20

Small-scale

0.847

High

681244

POMP
Proteasome maturation protein

3

7

Small-scale

0.847

High

681176

PSMG4
Proteasome assembly chaperone 4

2

4

High-throughput

0.811

High

681135

TERA
Transitional endoplasmic reticulum ATPase

2

11

Small-scale

0.737

High

137967

PSDE
26S proteasome non-ATPase regulatory subunit 14

6

20

Small-scale

0.721

High

681248

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

5

19

Small-scale

0.712

High

681134

PSMD4
26S proteasome non-ATPase regulatory subunit 4

5

12

Small-scale

0.709

High

681142

PSME3
Proteasome activator complex subunit 3

1

18

High-throughput

0.691

High

681201

PSMA8
Proteasome subunit alpha-type 8

1

19

High-throughput

0.691

High

681246

FBX7
F-box only protein 7

3

5

Small-scale

0.680

High

210859

PSMD3
26S proteasome non-ATPase regulatory subunit 3

3

9

Small-scale

0.667

High

681219

PSMD1
26S proteasome non-ATPase regulatory subunit 1

3

20

Small-scale

0.667

High

681166

PSMD6
26S proteasome non-ATPase regulatory subunit 6

3

20

Small-scale

0.662

High

681155

PSMD2
26S proteasome non-ATPase regulatory subunit 2

3

20

Small-scale

0.656

High

681156

CUL1
Cullin-1

3

8

Small-scale

0.656

High

681131

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

3

10

Small-scale

0.640

High

681151

UBE3A
Ubiquitin-protein ligase E3A

3

18

Small-scale

0.640

High

371202

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.611

High

681127

PSMD7
26S proteasome non-ATPase regulatory subunit 7

2

20

Small-scale

0.611

High

681147

SKP1
S-phase kinase-associated protein 1

2

10

Small-scale

0.611

High

681175

AKIR2
Akirin-2

2

8

Small-scale

0.611

High

681243

PSD13
26S proteasome non-ATPase regulatory subunit 13

2

11

Small-scale

0.611

High

681234

UBQL2
Ubiquilin-2

2

20

Small-scale

0.595

High

681133

RD23B
UV excision repair protein RAD23 homolog B

2

20

Small-scale

0.584

High

681170

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

9

Small-scale

0.584

High

681179

DDI2
Protein DDI1 homolog 2

2

20

Small-scale

0.584

High

681181

ECM29
Proteasome adapter and scaffold protein ECM29

2

14

Small-scale

0.584

High

681192

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

10

High-throughput

0.584

High

681194

CAND1
Cullin-associated NEDD8-dissociated protein 1

2

4

Small-scale

0.584

High

681210

FBXW7
F-box/WD repeat-containing protein 7

2

5

Small-scale

0.584

High

114582

H0YKT8
Proteasome subunit beta

1

17

High-throughput

0.575

High

681138

SEM1
26S proteasome complex subunit SEM1

2

3

Small-scale

0.571

High

529115

TAU
Microtubule-associated protein tau

2

7

High-throughput

0.552

High

361119

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

389045

FINC
Fibronectin

1

6

High-throughput

0.536

High

539657

MBL2
Mannose-binding protein C

1

2

High-throughput

0.536

High

542339

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

563228

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.536

High

681126

PSN1
Presenilin-1

1

4

High-throughput

0.536

High

681128

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.536

High

681136

PCBP3
Poly(rC)-binding protein 3

1

2

High-throughput

0.536

High

681167

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

11

High-throughput

0.536

High

681184

RBP10
Ran-binding protein 10

1

3

High-throughput

0.536

High

681188

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

5

High-throughput

0.536

High

681193

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

19

High-throughput

0.536

High

681222

SLX1
Structure-specific endonuclease subunit SLX1

1

5

High-throughput

0.536

High

681230

AKIR1
Akirin-1

1

8

High-throughput

0.536

High

681237

AMFR
E3 ubiquitin-protein ligase AMFR

1

12

High-throughput

0.536

High

648089

NDKB
Nucleoside diphosphate kinase B

1

4

High-throughput

0.515

High

97060

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.514

High

181970

UBD
Ubiquitin D

1

20

Small-scale

0.501

High

681103

IKBA
NF-kappa-B inhibitor alpha

1

6

Small-scale

0.501

High

681150

CCNA1
Cyclin-A1

1

2

Small-scale

0.501

High

339657

KLF8
Krueppel-like factor 8

1

17

High-throughput

0.500

High

681158

KLF5
Krueppel-like factor 5

1

18

High-throughput

0.500

High

681225

KLF16
Krueppel-like factor 16

1

17

High-throughput

0.500

High

681235

KLF15
Krueppel-like factor 15

1

17

High-throughput

0.500

High

261697

HUS1
Checkpoint protein HUS1

1

0

High-throughput

0.493

High

681196

CACL1
CDK2-associated and cullin domain-containing protein 1

1

9

High-throughput

0.489

High

681232

HOME3
Homer protein homolog 3

1

3

High-throughput

0.481

High

143558

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

6

High-throughput

0.479

High

169958

AURKA
Aurora kinase A

1

8

High-throughput

0.479

High

240794

PRKN
E3 ubiquitin-protein ligase parkin

1

19

Small-scale

0.479

High

259466

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

271908

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

293228

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

294827

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

3

High-throughput

0.479

High

315140

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

324551

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

326516

MFN2
Mitofusin-2

1

4

High-throughput

0.479

High

347533

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.479

High

352981

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.479

High

425320

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

468090

HS90B
Heat shock protein HSP 90-beta

1

5

Small-scale

0.479

High

507087

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

Small-scale

0.479

High

507550

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.479

High

519755

ANDR
Androgen receptor

1

7

High-throughput

0.479

High

520748

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

4

High-throughput

0.479

High

534660

BIP
Endoplasmic reticulum chaperone BiP

1

6

Small-scale

0.479

High

536533

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

587953

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

606250

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

607528

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

6

High-throughput

0.479

High

681104

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

681111

3MG
DNA-3-methyladenine glycosylase

1

1

High-throughput

0.479

High

681112

NOS2
Nitric oxide synthase, inducible

1

5

High-throughput

0.479

High

681113

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

681114

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

681117

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.479

High

681119

MAP1B
Microtubule-associated protein 1B

1

6

High-throughput

0.479

High

681120

YAP1
Transcriptional coactivator YAP1

1

13

High-throughput

0.479

High

681121

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

5

Small-scale

0.479

High

681122

TCPG
T-complex protein 1 subunit gamma

1

1

Small-scale

0.479

High

681129

PLK1
Serine/threonine-protein kinase PLK1

1

15

Small-scale

0.479

High

681130

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

681132

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.479

High

681137

FBXW4
F-box/WD repeat-containing protein 4

1

6

Small-scale

0.479

High

681140

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.479

High

681141

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

681146

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.479

High

681148

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

681149

RNF4
E3 ubiquitin-protein ligase RNF4

1

7

High-throughput

0.479

High

681153

DUS4
Dual specificity protein phosphatase 4

1

2

High-throughput

0.479

High

681154

PAK2
Serine/threonine-protein kinase PAK 2

1

6

High-throughput

0.479

High

681157

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

681160

TRI14
Tripartite motif-containing protein 14

1

7

High-throughput

0.479

High

681161

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

6

High-throughput

0.479

High

681162

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

9

Small-scale

0.479

High

681164

RBM39
RNA-binding protein 39

1

4

High-throughput

0.479

High

681168

UBE3C
Ubiquitin-protein ligase E3C

1

20

Small-scale

0.479

High

681169

NEDD8
Ubiquitin-like protein NEDD8

1

14

Small-scale

0.479

High

681171

MK06
Mitogen-activated protein kinase 6

1

5

High-throughput

0.479

High

681172

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

681173

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

681174

MIDN
Midnolin

1

5

High-throughput

0.479

High

681180

TET5C
Terminal nucleotidyltransferase 5C

1

2

High-throughput

0.479

High

681182

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

681183

DESI1
Desumoylating isopeptidase 1

1

6

Small-scale

0.479

High

681186

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.479

High

681187

SEML
Putative protein SEM1, isoform 2

1

3

High-throughput

0.479

High

681189

MOB3C
MOB kinase activator 3C

1

6

High-throughput

0.479

High

681190

MEPCE
7SK snRNA methylphosphate capping enzyme

1

4

High-throughput

0.479

High

681195

GOLI
E3 ubiquitin-protein ligase RNF130

1

18

High-throughput

0.479

High

681200

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

681202

RBCC1
RB1-inducible coiled-coil protein 1

1

3

High-throughput

0.479

High

681205

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.479

High

681207

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

19

High-throughput

0.479

High

681208

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

681209

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

Small-scale

0.479

High

681212

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

681213

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

5

Small-scale

0.479

High

681214

CI072
Guanine nucleotide exchange factor C9orf72

1

5

High-throughput

0.479

High

681220

TCPH
T-complex protein 1 subunit eta

1

1

Small-scale

0.479

High

681221

ANM1
Protein arginine N-methyltransferase 1

1

3

Small-scale

0.479

High

681223

PAAF1
Proteasomal ATPase-associated factor 1

1

7

Small-scale

0.479

High

681226

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

10

Small-scale

0.479

High

681227

ATG5
Autophagy protein 5

1

3

High-throughput

0.479

High

681228

TXNIP
Thioredoxin-interacting protein

1

3

Small-scale

0.479

High

681229

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

681233

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

681236

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.479

High

681240

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

681241

PRP19
Pre-mRNA-processing factor 19

1

5

Small-scale

0.479

High

681242

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

681245

NINL
Ninein-like protein

1

3

High-throughput

0.479

High

681247

TRAF6
TNF receptor-associated factor 6

1

9

High-throughput

0.479

High

681216

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

681218

CDC5L
Cell division cycle 5-like protein

1

0

Small-scale

0.458

High

681231

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

681239

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.458

High

429328

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

668198

CXCR2
C-X-C chemokine receptor type 2

1

1

Small-scale

0.445

High

681159

DAG1
Dystroglycan 1

1

1

Small-scale

0.445

High

681197

CTL2
Choline transporter-like protein 2

1

13

High-throughput

0.445

High

681204

CTL1
Choline transporter-like protein 1

1

13

High-throughput

0.445

High

254526

EIF1B
Eukaryotic translation initiation factor 1b

1

3

High-throughput

0.437

High

411382

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

681163

GRM2
Metabotropic glutamate receptor 2

1

6

High-throughput

0.437

High

681198

FBXL6
F-box/LRR-repeat protein 6

1

3

High-throughput

0.437

High

681203

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

681249

INSI2
Insulin-induced gene 2 protein

1

3

Small-scale

0.437

High

681123

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

685

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.407

High

681177

TMM31
Transmembrane protein 31

1

5

High-throughput

0.407

High

681178

SL9C2
Sodium/hydrogen exchanger 11

1

4

High-throughput

0.407

High

681185

ZNT10
Calcium/manganese antiporter SLC30A10

1

7

High-throughput

0.407

High

681191

NIPA1
Magnesium transporter NIPA1

1

5

High-throughput

0.407

High

681199

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.407

High

681215

S26A8
Testis anion transporter 1

1

5

High-throughput

0.407

High


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Last updated: 11Aug2025