HitPredict

Interactor 1: DNJA1 (P31689)
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
Gene: DNAJA1

Interactor 2: AGO4 (Q9HCK5)
Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)
Gene: AGO4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19167051
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 397 Hs			1 861
+	Hs
		681603 DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00		AGO3_HUMAN (5-861): 0: 1146: 81.18
+	Hs
		243622 DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55		AGO4_HUMAN (1-861): 0: 1180: 100.00
+	Hs
		1262168 DNJA4_HUMAN (1-397): 1.01e-159: 456: 73.37		AGO2_HUMAN (12-861): 0: 1151: 78.94
+	Hs
		243666 DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55		AGO1_HUMAN (8-861): 0: 1157: 83.49
+	Ce
		108427 O45502_CAEEL (1-397): 1.92e-128: 377: 50.12		G5EGR6_CAEEL (13-861): 0: 1072: 64.77
+	Ce
		108407 O16303_CAEEL (4-395): 3.16e-123: 365: 42.99		G5EGR6_CAEEL (13-861): 0: 1072: 64.77
+	Hs
		1336281 DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15		AGO4_HUMAN (1-861): 0: 1180: 100.00
+	Hs
		1354288 DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15		AGO1_HUMAN (8-861): 0: 1157: 83.49