HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	36931259, 28514442, 33961781, 34349018
Identification Methods	proximity labelling technology, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~14-3-3
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0045296 - cadherin binding GO:0050815 - phosphoserine residue binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 248
+	Hs
		683936 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		909424 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	At
		788342 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14331_ARATH (3-241): 4.5e-144: 405: 56.85
+	At
		788518 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14333_ARATH (3-247): 2.63e-144: 405: 58.30
+	At
		965289 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14332_ARATH (3-248): 2.23e-144: 405: 58.47
+	At
		788392 14337_ARATH (1-239): 1.25e-144: 406: 61.73		14331_ARATH (3-241): 4.5e-144: 405: 56.85
+	At
		802000 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14334_ARATH (3-248): 1.23e-142: 401: 56.45
+	At
		965322 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14339_ARATH (2-244): 1.17e-142: 401: 55.56
+	At
		788692 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14335_ARATH (2-247): 4.54e-140: 395: 56.05
+	At
		965354 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14311_ARATH (2-244): 2.95e-138: 390: 57.20
+	At
		817051 14332_ARATH (1-241): 4.75e-145: 407: 63.27		14310_ARATH (2-247): 2.9e-137: 387: 53.63
+	Mm
		910224 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96
+	Hs
		909429 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		646775 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683249 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Dm
		664602 1433E_DROME (3-245): 4.63e-144: 405: 64.90		1433Z_DROME (1-245): 4.71e-99: 290: 66.12
+	Mm
		910331 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		1433B_MOUSE (1-239): 3.73e-99: 290: 68.62
+	Hs
		904421 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Mm
		905329 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Mm
		910226 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		1433F_MOUSE (2-242): 1.72e-96: 284: 64.20