HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	19592491, 23602568
Identification Methods	affinity chromatography technology, enzymatic study, protein kinase assay, coimmunoprecipitation
Interaction Type	physical association, direct interaction, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 688
+	Hs
		909447 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK3_HUMAN (378-688): 7.03e-93: 292: 17.41
+	Hs
		625306 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14
+	Hs
		683216 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KS6A3_HUMAN (2-362): 2.51e-78: 266: 13.83
+	Hs
		909590 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KS6A2_HUMAN (2-372): 3.86e-77: 263: 15.21
+	At
		965291 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CDPK1_ARATH (376-687): 7.66e-75: 254: 12.74
+	At
		965360 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CIPKC_ARATH (381-687): 7.94e-76: 253: 12.42
+	At
		1280891 14337_ARATH (1-239): 1.25e-144: 406: 61.73		CIPKC_ARATH (381-687): 7.94e-76: 253: 12.42
+	Hs
		910158 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SRPK3_HUMAN (450-687): 1.19e-63: 223: 66.39
+	Hs
		909877 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYRK2_HUMAN (51-234): 1.48e-62: 221: 29.35
+	Hs
		683206 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73
+	Hs
		834015 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11
+	At
		847169 14332_ARATH (1-241): 4.75e-145: 407: 63.27		AFC1_ARATH (476-687): 5.81e-63: 218: 22.98
+	Hs
		683207 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11
+	Hs
		910066 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYRK4_HUMAN (2-222): 1.98e-60: 213: 26.09
+	Hs
		910197 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYR1B_HUMAN (502-686): 8.03e-59: 211: 28.02
+	Hs
		909547 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK13_HUMAN (373-687): 1.6e-54: 204: 15.85
+	Hs
		910096 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK12_HUMAN (291-687): 5.8e-54: 203: 13.17
+	Dm
		955037 1433E_DROME (3-245): 4.63e-144: 405: 64.90		Q9VR61_DROME (69-348): 1.39e-36: 149: 15.39
+	Hs
		272852 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KS6A4_HUMAN (3-378): 1.53e-33: 139: 16.17
+	Hs
		909531 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KCC2G_HUMAN (376-686): 1.18e-29: 126: 16.51