HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~C1_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1732
+	Hs
		909658 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		927145 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		646981 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		904690 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		927164 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MRCKG_HUMAN (4-1712): 0: 1145: 39.90
+	At
		965360 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CIPKC_ARATH (52-527): 4.3e-135: 431: 18.54
+	At
		1280891 14337_ARATH (1-239): 1.25e-144: 406: 61.73		CIPKC_ARATH (52-527): 4.3e-135: 431: 18.54
+	At
		788672 14333_ARATH (3-241): 4.44e-143: 402: 62.96		CIPKC_ARATH (52-527): 4.3e-135: 431: 18.54
+	Hs
		681770 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		681776 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		681766 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		683365 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		STK38_HUMAN (66-404): 1.24e-89: 302: 45.07
+	Hs
		910180 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ST38L_HUMAN (66-416): 1.26e-88: 299: 43.15
+	Hs
		683831 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ST38L_HUMAN (66-416): 1.26e-88: 299: 43.15
+	Hs
		927070 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		STK38_HUMAN (66-404): 1.24e-89: 302: 45.07
+	Hs
		927572 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Hs
		270395 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KS6A5_HUMAN (60-334): 2.48e-72: 261: 27.46
+	Hs
		904584 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		STK38_HUMAN (66-404): 1.24e-89: 302: 45.07
+	Hs
		909524 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Mm
		926837 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KS6A5_MOUSE (75-147): 3.21e-12: 73.7: 23.38