Protein: IKBA
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)

Gene: IKBA, NFKBIA
Organism: Homo sapiens
Interactions: 232
UniProt ID: P25963

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

683443

TF65
Transcription factor p65

90

20

Small-scale

0.998

High

167824

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

83

20

Small-scale

0.998

High

177798

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

67

20

Small-scale

0.997

High

683541

FBW1A
F-box/WD repeat-containing protein 1A

29

20

Small-scale

0.993

High

626079

NFKB1
Nuclear factor NF-kappa-B p105 subunit

32

20

Small-scale

0.993

High

683546

NEMO
NF-kappa-B essential modulator

28

20

Small-scale

0.991

High

683531

FBW1B
F-box/WD repeat-containing protein 11

13

20

Small-scale

0.983

High

683444

REL
Proto-oncogene c-Rel

12

20

Small-scale

0.978

High

683431

SKP1
S-phase kinase-associated protein 1

9

6

Small-scale

0.969

High

683439

NFKB2
Nuclear factor NF-kappa-B p100 subunit

7

19

Small-scale

0.966

High

683454

CUL1
Cullin-1

9

20

Small-scale

0.966

High

683441

RELB
Transcription factor RelB

8

20

Small-scale

0.964

High

683416

TERA
Transitional endoplasmic reticulum ATPase

7

14

Small-scale

0.959

High

683461

IKBB
NF-kappa-B inhibitor beta

5

17

Small-scale

0.931

High

657982

RS3
Small ribosomal subunit protein uS3

5

2

Small-scale

0.925

High

557106

SRC
Proto-oncogene tyrosine-protein kinase Src

4

12

Small-scale

0.895

High

683384

IKBA
NF-kappa-B inhibitor alpha

4

19

Small-scale

0.886

High

413228

P53
Cellular tumor antigen p53

3

10

Small-scale

0.880

High

683460

KS6A1
Ribosomal protein S6 kinase alpha-1

3

10

Small-scale

0.878

High

683455

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

4

20

Small-scale

0.873

High

683456

CASL
Enhancer of filamentation 1

3

8

High-throughput

0.871

High

683424

RHOA
Transforming protein RhoA

3

20

High-throughput

0.861

High

683506

ANR27
Ankyrin repeat domain-containing protein 27

3

19

High-throughput

0.861

High

683534

NEB1
Neurabin-1

3

20

High-throughput

0.861

High

683530

TBK1
Serine/threonine-protein kinase TBK1

3

20

Small-scale

0.834

High

683457

PLSI
Plastin-1

2

20

High-throughput

0.811

High

683388

AKT1
RAC-alpha serine/threonine-protein kinase

2

14

Small-scale

0.770

High

683410

IRAK1
Interleukin-1 receptor-associated kinase 1

2

4

Small-scale

0.754

High

642511

TGM2
Protein-glutamine gamma-glutamyltransferase 2

2

2

Small-scale

0.737

High

683445

KPCZ
Protein kinase C zeta type

2

16

Small-scale

0.737

High

362166

ABL1
Tyrosine-protein kinase ABL1

1

12

Small-scale

0.724

High

683470

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

5

Small-scale

0.724

High

683526

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

5

20

Small-scale

0.722

High

483834

CD7
T-cell antigen CD7

1

2

High-throughput

0.698

High

667176

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

1

Small-scale

0.697

High

683486

COMD1
COMM domain-containing protein 1

4

2

Small-scale

0.694

High

669101

ARBK1
Beta-adrenergic receptor kinase 1

1

13

Small-scale

0.692

High

683394

GRK5
G protein-coupled receptor kinase 5

1

10

Small-scale

0.692

High

127763

IKBE
NF-kappa-B inhibitor epsilon

1

19

High-throughput

0.691

High

683400

MTOR
Serine/threonine-protein kinase mTOR

1

12

Small-scale

0.691

High

683437

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.691

High

683447

PTN13
Tyrosine-protein phosphatase non-receptor type 13

4

20

Small-scale

0.680

High

683404

ARRB1
Beta-arrestin-1

3

3

Small-scale

0.669

High

683505

P121A
Nuclear envelope pore membrane protein POM 121

3

13

High-throughput

0.667

High

683462

TBCE
Tubulin-specific chaperone E

3

5

High-throughput

0.667

High

683472

CYTSA
Cytospin-A

3

13

High-throughput

0.667

High

683500

SPDLY
Protein Spindly

3

9

High-throughput

0.667

High

683535

TBC24
TBC1 domain family member 24

3

1

High-throughput

0.667

High

683435

CSK2B
Casein kinase II subunit beta

3

2

Small-scale

0.660

High

134241

RPOM
DNA-directed RNA polymerase, mitochondrial

5

1

Small-scale

0.652

High

683434

UBC9
SUMO-conjugating enzyme UBC9

3

11

Small-scale

0.650

High

169959

AURKA
Aurora kinase A

1

11

Small-scale

0.647

High

603169

KPCA
Protein kinase C alpha type

1

14

Small-scale

0.647

High

683412

KS6A3
Ribosomal protein S6 kinase alpha-3

1

8

Small-scale

0.647

High

683449

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

6

Small-scale

0.647

High

683509

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

20

Small-scale

0.647

High

681571

PSA4
Proteasome subunit alpha type-4

3

5

Small-scale

0.640

High

220675

DENR
Density-regulated protein

3

0

High-throughput

0.638

High

683497

AIDA
Axin interactor, dorsalization-associated protein

3

0

High-throughput

0.638

High

683518

ARMT1
Damage-control phosphatase ARMT1

3

0

High-throughput

0.638

High

683389

ARRB2
Beta-arrestin-2

2

3

Small-scale

0.634

High

683502

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

2

12

Small-scale

0.634

High

327550

ELP1
Elongator complex protein 1

3

0

Small-scale

0.628

High

683473

SUMO4
Small ubiquitin-related modifier 4

2

4

Small-scale

0.625

High

683415

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

3

Small-scale

0.624

High

683510

BARD1
BRCA1-associated RING domain protein 1

1

18

Small-scale

0.621

High

683442

CO7A1
Collagen alpha-1(VII) chain

1

9

High-throughput

0.618

High

334508

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

5

Small-scale

0.618

High

407986

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.618

High

457240

TBB5
Tubulin beta chain

1

20

High-throughput

0.618

High

462991

YES
Tyrosine-protein kinase Yes

1

13

High-throughput

0.618

High

683402

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

8

Small-scale

0.618

High

683403

KC1A
Casein kinase I isoform alpha

1

8

Small-scale

0.618

High

683419

ARL4C
ADP-ribosylation factor-like protein 4C

1

7

High-throughput

0.618

High

683426

PRS8
26S proteasome regulatory subunit 8

1

5

Small-scale

0.618

High

683427

RAN
GTP-binding nuclear protein Ran

1

9

Small-scale

0.618

High

683464

MK14
Mitogen-activated protein kinase 14

1

10

Small-scale

0.618

High

683474

SFRP4
Secreted frizzled-related protein 4

1

2

Small-scale

0.618

High

683477

TBA1A
Tubulin alpha-1A chain

1

20

High-throughput

0.618

High

683485

FBXW8
F-box/WD repeat-containing protein 8

1

20

Small-scale

0.618

High

683495

FBXW7
F-box/WD repeat-containing protein 7

1

20

Small-scale

0.618

High

683507

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

8

Small-scale

0.618

High

683508

ASB2
Ankyrin repeat and SOCS box protein 2

1

19

Small-scale

0.618

High

683523

CISH
Cytokine-inducible SH2-containing protein

1

20

Small-scale

0.618

High

683529

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

11

Small-scale

0.618

High

683545

NCOR2
Nuclear receptor corepressor 2

2

13

Small-scale

0.612

High

654615

TCEA1
Transcription elongation factor A protein 1

2

6

High-throughput

0.611

High

683432

GBG5

2

1

High-throughput

0.611

High

683450

BIRC2
Baculoviral IAP repeat-containing protein 2

2

20

High-throughput

0.611

High

683522

PRDC1
Phosphoribosyltransferase domain-containing protein 1

2

1

High-throughput

0.611

High

683503

SCRN2
Secernin-2

3

1

High-throughput

0.609

High

683525

CUED1
CUE domain-containing protein 1

3

1

High-throughput

0.609

High

683533

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

3

2

High-throughput

0.609

High

210862

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

2

High-throughput

0.606

High

683417

TCL1A
T-cell leukemia/lymphoma protein 1A

2

1

High-throughput

0.606

High

683420

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

12

Small-scale

0.602

High

507552

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

12

Small-scale

0.601

High

669816

MCM3
DNA replication licensing factor MCM3

2

9

Small-scale

0.601

High

680773

PSA1
Proteasome subunit alpha type-1

2

5

Small-scale

0.601

High

683390

MCM5
DNA replication licensing factor MCM5

2

6

Small-scale

0.601

High

683391

MCM7
DNA replication licensing factor MCM7

2

6

Small-scale

0.601

High

683408

RBP2
E3 SUMO-protein ligase RanBP2

2

7

Small-scale

0.601

High

683493

HDAC2
Histone deacetylase 2

2

20

Small-scale

0.601

High

683411

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

12

Small-scale

0.594

High

683492

ASB17
Ankyrin repeat and SOCS box protein 17

1

0

Small-scale

0.586

High

415357

HSPB1
Heat shock protein beta-1

2

5

Small-scale

0.584

High

683446

EP300
Histone acetyltransferase p300

2

12

Small-scale

0.584

High

683448

CSN1
COP9 signalosome complex subunit 1

2

3

Small-scale

0.584

High

683468

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

6

Small-scale

0.584

High

683513

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

584476

VAV
Proto-oncogene vav

1

5

Small-scale

0.575

High

683459

CASP8
Caspase-8

1

1

Small-scale

0.575

High

683430

DYL1
Dynein light chain 1, cytoplasmic

1

1

Small-scale

0.573

High

683496

PMEPA
Protein TMEPAI

1

1

Small-scale

0.573

High

610990

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

10

Small-scale

0.571

High

683440

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

12

Small-scale

0.571

High

683386

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

16

Small-scale

0.568

High

484930

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

Small-scale

0.561

High

551954

ADT1
ADP/ATP translocase 1

1

15

Small-scale

0.561

High

683466

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

13

Small-scale

0.561

High

683484

TRI22
E3 ubiquitin-protein ligase TRIM22

1

9

Small-scale

0.561

High

683537

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

Small-scale

0.561

High

683428

RL23
Large ribosomal subunit protein uL14

2

0

Small-scale

0.559

High

683451

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

Small-scale

0.559

High

683536

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

Small-scale

0.553

High

248198

NDK8
Putative nucleoside diphosphate kinase

2

2

High-throughput

0.552

High

621560

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.541

High

683543

RWDD3
RWD domain-containing protein 3

1

0

Small-scale

0.537

High

683395

CTNA1
Catenin alpha-1

1

5

Small-scale

0.536

High

683406

CENPF
Centromere protein F

1

20

High-throughput

0.536

High

683463

NEDD8
Ubiquitin-like protein NEDD8

1

7

Small-scale

0.536

High

683512

RHG39
Rho GTPase-activating protein 39

1

8

High-throughput

0.536

High

683398

CASR
Extracellular calcium-sensing receptor

1

0

Small-scale

0.529

High

48909

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.518

High

194776

MEFV
Pyrin

1

10

Small-scale

0.515

High

278241

NCOR1
Nuclear receptor corepressor 1

1

19

Small-scale

0.515

High

333941

SMC2
Structural maintenance of chromosomes protein 2

1

11

Small-scale

0.515

High

683387

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

6

Small-scale

0.515

High

683397

MDHC
Malate dehydrogenase, cytoplasmic

1

4

High-throughput

0.515

High

683407

NU153
Nuclear pore complex protein Nup153

1

19

Small-scale

0.515

High

683409

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

7

Small-scale

0.515

High

683418

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.515

High

683422

CSN2
COP9 signalosome complex subunit 2

1

2

Small-scale

0.515

High

683452

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.515

High

683458

SMC1A
Structural maintenance of chromosomes protein 1A

1

11

Small-scale

0.515

High

683524

SMC4
Structural maintenance of chromosomes protein 4

1

13

Small-scale

0.515

High

683540

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.515

High

683487

AVL9
Late secretory pathway protein AVL9 homolog

1

0

High-throughput

0.513

High

683501

GNA1
Glucosamine 6-phosphate N-acetyltransferase

1

0

High-throughput

0.513

High

683532

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.513

High

683542

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

683514

IKZF4
Zinc finger protein Eos

1

2

Small-scale

0.508

High

683528

ZN212
Zinc finger protein 212

1

3

Small-scale

0.508

High

213816

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

11

Small-scale

0.501

High

377972

TNFA
Tumor necrosis factor

1

3

Small-scale

0.501

High

457044

CAN1
Calpain-1 catalytic subunit

1

3

Small-scale

0.501

High

484818

HXB7
Homeobox protein Hox-B7

1

20

Small-scale

0.501

High

558958

LYL1
Protein lyl-1

1

7

Small-scale

0.501

High

681103

PSA2
Proteasome subunit alpha type-2

1

6

Small-scale

0.501

High

683405

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

10

Small-scale

0.501

High

683421

UBC12
NEDD8-conjugating enzyme Ubc12

1

10

Small-scale

0.501

High

683429

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

12

Small-scale

0.501

High

683436

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

11

Small-scale

0.501

High

683544

RN115
E3 ubiquitin-protein ligase RNF115

1

2

Small-scale

0.501

High

683521

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.494

High

617200

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.486

High

142178

PIR
Pirin

1

1

Small-scale

0.481

High

683453

ITPK1
Inositol-tetrakisphosphate 1-kinase

1

0

Small-scale

0.480

High

65479

TRI64
Tripartite motif-containing protein 64

1

9

Small-scale

0.479

High

155912

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.479

High

172487

XPO1
Exportin-1

1

20

High-throughput

0.479

High

188177

HDAC3
Histone deacetylase 3

1

17

Small-scale

0.479

High

247081

TBCD4
TBC1 domain family member 4

1

1

Small-scale

0.479

High

252959

PDE8A
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

1

3

Small-scale

0.479

High

353846

BCL10
B-cell lymphoma/leukemia 10

1

1

Small-scale

0.479

High

402855

ANXA1
Annexin A1

1

6

High-throughput

0.479

High

424780

ADT2
ADP/ATP translocase 2

1

15

High-throughput

0.479

High

429330

JUN
Transcription factor Jun

1

11

Small-scale

0.479

High

474493

VIME
Vimentin

1

14

Small-scale

0.479

High

482324

F16P1
Fructose-1,6-bisphosphatase 1

1

3

High-throughput

0.479

High

488406

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

7

Small-scale

0.479

High

533592

CLUS
Clusterin

1

1

Small-scale

0.479

High

534662

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

536537

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

571876

TRI27
Zinc finger protein RFP

1

10

Small-scale

0.479

High

683385

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

4

Small-scale

0.479

High

683392

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.479

High

683393

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

683396

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

683399

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

8

Small-scale

0.479

High

683401

RS27
Small ribosomal subunit protein eS27

1

6

Small-scale

0.479

High

683413

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

1

High-throughput

0.479

High

683414

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

683423

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

High-throughput

0.479

High

683425

SUMO2
Small ubiquitin-related modifier 2

1

4

Small-scale

0.479

High

683433

ACTG
Actin, cytoplasmic 2

1

11

High-throughput

0.479

High

683438

CLH1
Clathrin heavy chain 1

1

6

High-throughput

0.479

High

683465

H31T
Histone H3.1t

1

4

Small-scale

0.479

High

683469

AMOT
Angiomotin

1

17

Small-scale

0.479

High

683471

DCAF6
DDB1- and CUL4-associated factor 6

1

9

High-throughput

0.479

High

683476

MEAK7
MTOR-associated protein MEAK7

1

1

High-throughput

0.479

High

683478

RS27L
Ribosomal protein eS27-like

1

6

High-throughput

0.479

High

683479

MAVS
Mitochondrial antiviral-signaling protein

1

10

Small-scale

0.479

High

683481

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

19

Small-scale

0.479

High

683482

PATL1
Protein PAT1 homolog 1

1

6

Small-scale

0.479

High

683483

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

7

Small-scale

0.479

High

683488

NEDD1
Protein NEDD1

1

7

Small-scale

0.479

High

683489

COP1
E3 ubiquitin-protein ligase COP1

1

12

Small-scale

0.479

High

683494

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

1

Small-scale

0.479

High

683499

REPS1
RalBP1-associated Eps domain-containing protein 1

1

17

Small-scale

0.479

High

683511

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

13

Small-scale

0.479

High

683515

RPAP3
RNA polymerase II-associated protein 3

1

15

Small-scale

0.479

High

683516

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.479

High

683520

4ET
Eukaryotic translation initiation factor 4E transporter

1

3

Small-scale

0.479

High

683527

SPRR3
Small proline-rich protein 3

1

6

High-throughput

0.479

High

683538

CSN3
COP9 signalosome complex subunit 3

1

4

Small-scale

0.479

High

467374

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.458

High

683467

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.458

High

683490

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.458

High

683491

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

1

0

High-throughput

0.458

High

683504

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.458

High

683519

ELP3
Elongator complex protein 3

1

0

High-throughput

0.458

High

108065

G3V3R7
ubiquitinyl hydrolase 1

1

1

High-throughput

0.445

High

71796

CMA1B
Ciliary microtubule associated protein 1B

1

1

Small-scale

0.437

High

683480

TRI46
Tripartite motif-containing protein 46

1

20

Small-scale

0.437

High

683539

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.437

High

350281

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.279

Low

683475

PTRD1
Putative peptidyl-tRNA hydrolase PTRHD1

1

0

High-throughput

0.279

Low

156524

UBFD1
Ubiquitin domain-containing protein UBFD1

1

0

High-throughput

0.249

Low

683498

RN183
E3 ubiquitin-protein ligase RNF183

1

0

Small-scale

0.249

Low

683517

RN121
E3 ubiquitin ligase RNF121

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025