HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 7388
+	Hs
		910159 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		927659 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Mm
		93548 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		DESP_MOUSE (2737-3805): 1.11e-27: 127: 8.89
+	Mm
		926889 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		PLEC_MOUSE (5698-7245): 3.41e-29: 132: 9.08
+	Hs
		551660 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		927068 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		926965 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ACTN3_HUMAN (5633-6111): 4.77e-17: 92.1: 12.20
+	Hs
		909464 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		683282 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		297821 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		K0754_HUMAN (757-1741): 1.73e-10: 70.9: 10.05
+	Hs
		926949 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		297815 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		K0754_HUMAN (757-1741): 1.73e-10: 70.9: 10.05
+	Hs
		909544 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		683333 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Mm
		926806 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		SPTB2_MOUSE (6378-7134): 3.94e-11: 72.8: 13.67
+	Hs
		926931 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Mm
		926814 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		Q68FG2_MOUSE (330-850): 2.48e-10: 70.5: 12.57
+	Hs
		297824 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		K0754_HUMAN (757-1741): 1.73e-10: 70.9: 10.05
+	Hs
		927025 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Mm
		82753 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		B9EKJ1_MOUSE (433-1344): 4.47e-09: 66.1: 13.69