HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	10869435, 21081666, 23752268, 33961781, 35271311, 24255178, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1122
+	Hs
		910173 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		927670 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Mm
		910239 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		Q3UJF1_MOUSE (1-1122): 0: 717: 92.71
+	Mm
		910352 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		HDAC5_MOUSE (1-1122): 0: 713: 92.17
+	Hs
		880661 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		683230 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		880673 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Mm
		1157809 1433B_MOUSE (1-246): 5.56e-141: 396: 98.78		HDAC4_MOUSE (1-1103): 0: 651: 53.34
+	Hs
		910144 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		HDAC9_HUMAN (25-1055): 0: 608: 56.33
+	Hs
		927642 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		HDAC9_HUMAN (25-1055): 0: 608: 56.33
+	Hs
		909856 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		683574 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		927340 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		909530 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		927372 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Dm
		664611 1433Z_DROME (2-246): 4.79e-141: 396: 78.78		Q59E49_DROME (135-1121): 3.58e-143: 463: 30.18
+	Mm
		910299 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		HDAC7_MOUSE (191-1122): 3.04e-139: 446: 37.55
+	Hs
		177251 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Hs
		910121 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Hs
		927619 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97