HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: GSK3A (P49840)
Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
Gene: GSK3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27684187, 36931259
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 248 Hs			1 483
+	Hs
		835306 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Hs
		683964 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		CDK3_HUMAN (116-425): 2.95e-138: 401: 30.50
+	Hs
		625306 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		CDK2_HUMAN (116-413): 1.52e-147: 425: 32.03
+	Bt
		61645 1433Z_BOVIN (1-242): 8.3e-142: 398: 70.66		A6H7A9_BOVIN (65-473): 2.45e-142: 417: 73.46
+	Hs
		909447 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		CDK3_HUMAN (116-425): 2.95e-138: 401: 30.50
+	Hs
		625334 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		CDK2_HUMAN (116-413): 1.52e-147: 425: 32.03
+	Hs
		835641 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41
+	Hs
		646731 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Hs
		683210 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Hs
		835301 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Hs
		625130 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		CDK2_HUMAN (116-413): 1.52e-147: 425: 32.03
+	Hs
		835337 1433F_HUMAN (2-242): 2.78e-96: 283: 64.20		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Hs
		683211 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41
+	Hs
		625296 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		CDK2_HUMAN (116-413): 1.52e-147: 425: 32.03
+	Hs
		646799 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		CDK3_HUMAN (116-425): 2.95e-138: 401: 30.50
+	Hs
		625383 1433F_HUMAN (2-242): 2.78e-96: 283: 64.20		CDK2_HUMAN (116-413): 1.52e-147: 425: 32.03
+	Hs
		683268 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		CDK3_HUMAN (116-425): 2.95e-138: 401: 30.50
+	Hs
		960082 1433F_HUMAN (2-242): 2.78e-96: 283: 64.20		CDK3_HUMAN (116-425): 2.95e-138: 401: 30.50