HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: M3K21 (Q5TCX8)
Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)
Gene: MAP3K21

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1036
+	Hs
		909655 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K21_HUMAN (1-1036): 0: 701: 100.00
+	Hs
		683977 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M3K10_HUMAN (32-1021): 0: 570: 44.87
+	Hs
		683959 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M3K9_HUMAN (38-1036): 0: 561: 47.56
+	Hs
		909462 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K10_HUMAN (32-1021): 0: 570: 44.87
+	Hs
		909438 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K9_HUMAN (38-1036): 0: 561: 47.56
+	Hs
		926946 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		M3K10_HUMAN (32-1021): 0: 570: 44.87
+	Hs
		926918 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		M3K9_HUMAN (38-1036): 0: 561: 47.56
+	Hs
		684359 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M3K20_HUMAN (117-932): 2.36e-131: 419: 21.37
+	Hs
		684206 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MINK1_HUMAN (104-1027): 1.61e-122: 408: 15.40
+	Hs
		337367 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ABL1_HUMAN (68-887): 6.57e-122: 402: 18.07
+	Hs
		684316 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK2_HUMAN (124-1029): 1.57e-119: 391: 17.95
+	Hs
		910094 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K20_HUMAN (117-932): 2.36e-131: 419: 21.37
+	Hs
		909810 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MINK1_HUMAN (104-1027): 1.61e-122: 408: 15.40
+	At
		1277300 14337_ARATH (2-247): 4.35e-147: 413: 58.07		SERK1_ARATH (1-443): 8.68e-128: 403: 18.97
+	Hs
		337416 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ABL1_HUMAN (68-887): 6.57e-122: 402: 18.07
+	At
		965327 14332_ARATH (3-248): 2.23e-144: 405: 58.47		PBS1_ARATH (61-498): 1.57e-131: 407: 20.22
+	At
		965320 14332_ARATH (3-248): 2.23e-144: 405: 58.47		BAK1_ARATH (1-450): 1.24e-126: 400: 19.03
+	Hs
		910013 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SIK2_HUMAN (124-1029): 1.57e-119: 391: 17.95
+	At
		788521 14333_ARATH (3-247): 2.63e-144: 405: 58.30		PBL9_ARATH (57-403): 1.03e-123: 385: 20.11
+	Hs
		337420 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ABL1_HUMAN (68-887): 6.57e-122: 402: 18.07