Protein: RL22A
Large ribosomal subunit protein eL22A (60S ribosomal protein L22-A) (L1c) (RP4) (YL31)

Gene: RL22A, RPL22A
Organism: Saccharomyces cerevisiae S288C
Interactions: 224
UniProt ID: P05749

Gene Ontology (top 5):
GO:0002181 - cytoplasmic translation
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome
GO:0005829 - cytosol
GO:0022625 - cytosolic large ribosomal subunit

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

434512

HSC82
ATP-dependent molecular chaperone HSC82

3

1

High-throughput

0.633

High

434500

RL19B
Large ribosomal subunit protein eL19

1

2

High-throughput

0.618

High

409648

RL24A
Large ribosomal subunit protein eL24A

2

4

High-throughput

0.584

High

409827

RL25
Large ribosomal subunit protein uL23

2

4

High-throughput

0.584

High

433331

RL26A
Large ribosomal subunit protein uL24A

2

4

High-throughput

0.584

High

434486

RL31A
Large ribosomal subunit protein eL31A

2

4

High-throughput

0.584

High

434528

RL16A
Large ribosomal subunit protein uL13A

2

3

High-throughput

0.584

High

434610

RL38
Large ribosomal subunit protein eL38

2

2

High-throughput

0.584

High

434661

TMA46
Translation machinery-associated protein 46

2

1

High-throughput

0.584

High

434476

RS14A
Small ribosomal subunit protein uS11A

2

0

High-throughput

0.559

High

434624

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

434634

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

434625

NOG2
Nucleolar GTP-binding protein 2

2

5

Small-scale

0.533

High

434522

SIS1
Protein SIS1

1

1

High-throughput

0.515

High

434555

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

2

1

Small-scale

0.504

High

149472

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

154107

RL36B
Large ribosomal subunit protein eL36B

1

2

High-throughput

0.479

High

383047

RLA4
Large ribosomal subunit protein P2B

1

3

High-throughput

0.479

High

391976

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

427060

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.479

High

427514

RLA1
Large ribosomal subunit protein P1A

1

2

High-throughput

0.479

High

427636

RLA2
Large ribosomal subunit protein P2A

1

3

High-throughput

0.479

High

432437

RL7A
Large ribosomal subunit protein uL30A

1

3

High-throughput

0.479

High

432761

RL9A
Large ribosomal subunit protein uL6A

1

3

High-throughput

0.479

High

432945

RL6B
Large ribosomal subunit protein eL6B

1

2

High-throughput

0.479

High

433103

RL17A
Large ribosomal subunit protein uL22A

1

2

High-throughput

0.479

High

433933

RL33A
Large ribosomal subunit protein eL33A

1

2

High-throughput

0.479

High

434108

RL36A
Large ribosomal subunit protein eL36A

1

2

High-throughput

0.479

High

434286

RL15A
Large ribosomal subunit protein eL15A

1

1

High-throughput

0.479

High

434473

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.479

High

434475

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.479

High

434478

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

434479

RS19B
Small ribosomal subunit protein eS19B

1

1

High-throughput

0.479

High

434481

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

1

High-throughput

0.479

High

434483

RL11A
Large ribosomal subunit protein uL5A

1

4

High-throughput

0.479

High

434484

RL27A
Large ribosomal subunit protein eL27A

1

2

High-throughput

0.479

High

434485

RL27B
Large ribosomal subunit protein eL27B

1

2

High-throughput

0.479

High

434487

RL31B
Large ribosomal subunit protein eL31B

1

4

High-throughput

0.479

High

434489

RL43B
Large ribosomal subunit protein eL43B

1

2

High-throughput

0.479

High

434492

RS4A
Small ribosomal subunit protein eS4A

1

1

High-throughput

0.479

High

434493

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

434495

RL1A
Large ribosomal subunit protein uL1A

1

1

High-throughput

0.479

High

434496

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.479

High

434497

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.479

High

434498

RL12B
Large ribosomal subunit protein uL11B

1

2

High-throughput

0.479

High

434501

RL35A
Large ribosomal subunit protein uL29A

1

1

High-throughput

0.479

High

434504

RLA3
Large ribosomal subunit protein P1B

1

2

High-throughput

0.479

High

434505

RL4A
Large ribosomal subunit protein uL4A

1

4

High-throughput

0.479

High

434509

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.479

High

434510

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

434514

RL8A
Large ribosomal subunit protein eL8A

1

3

High-throughput

0.479

High

434518

RS3A2
Small ribosomal subunit protein eS1B

1

2

High-throughput

0.479

High

434520

RL24B
Large ribosomal subunit protein eL24B

1

4

High-throughput

0.479

High

434524

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

434525

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

434526

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.479

High

434527

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.479

High

434529

RL16B
Large ribosomal subunit protein uL13B

1

3

High-throughput

0.479

High

434530

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

434533

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.479

High

434535

ZUO1
Zuotin

1

5

High-throughput

0.479

High

434537

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

434540

LHP1
La protein homolog

1

2

High-throughput

0.479

High

434541

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

434545

RL14A
Large ribosomal subunit protein eL14A

1

3

High-throughput

0.479

High

434548

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

434549

RL32
Large ribosomal subunit protein eL32

1

2

High-throughput

0.479

High

434551

MAK5
ATP-dependent RNA helicase MAK5

1

5

High-throughput

0.479

High

434561

RL14B
Large ribosomal subunit protein eL14B

1

3

High-throughput

0.479

High

434567

RPN10
26S proteasome regulatory subunit RPN10

1

1

Small-scale

0.479

High

434568

STM1
Suppressor protein STM1

1

1

High-throughput

0.479

High

434573

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

434575

RBG1
Ribosome-interacting GTPase 1

1

3

High-throughput

0.479

High

434576

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.479

High

434577

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

434579

RS26B
Small ribosomal subunit protein eS26B

1

1

High-throughput

0.479

High

434581

NUG1
Nuclear GTP-binding protein NUG1

1

5

High-throughput

0.479

High

434586

RL13B
Large ribosomal subunit protein eL13B

1

3

High-throughput

0.479

High

434591

RL34B
Large ribosomal subunit protein eL34B

1

2

High-throughput

0.479

High

434593

RLP7
Ribosome biogenesis protein RLP7

1

3

High-throughput

0.479

High

434595

RL33B
Large ribosomal subunit protein eL33B

1

2

High-throughput

0.479

High

434596

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

434600

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.479

High

434601

RL17B
Large ribosomal subunit protein uL22B

1

2

High-throughput

0.479

High

434606

RS7B
Small ribosomal subunit protein eS7B

1

1

High-throughput

0.479

High

434609

RL37A
Large ribosomal subunit protein eL37A

1

2

High-throughput

0.479

High

434611

RL4B
Large ribosomal subunit protein uL4B

1

4

High-throughput

0.479

High

434613

RL9B
Large ribosomal subunit protein uL6B

1

3

High-throughput

0.479

High

434614

RL37B
Large ribosomal subunit protein eL37B

1

2

High-throughput

0.479

High

434617

LSG1
Large subunit GTPase 1

1

5

High-throughput

0.479

High

434618

RL26B
Large ribosomal subunit protein uL24B

1

4

High-throughput

0.479

High

434627

JJJ1
J protein JJJ1

1

2

High-throughput

0.479

High

434628

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

434629

NOP15
Ribosome biogenesis protein 15

1

1

High-throughput

0.479

High

434632

RL22B
Large ribosomal subunit protein eL22B

1

3

High-throughput

0.479

High

434633

RL34A
Large ribosomal subunit protein eL34A

1

2

High-throughput

0.479

High

434637

RL6A
Large ribosomal subunit protein eL6A

1

2

High-throughput

0.479

High

434639

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

3

High-throughput

0.479

High

434640

RL21A
Large ribosomal subunit protein eL21A

1

2

High-throughput

0.479

High

434642

RLI1
Translation initiation factor RLI1

1

1

High-throughput

0.479

High

434644

HAS1
ATP-dependent RNA helicase HAS1

1

5

High-throughput

0.479

High

434646

HMO1
High mobility group protein 1

1

1

High-throughput

0.479

High

434647

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

434648

VMS1
tRNA endonuclease VMS1

1

2

High-throughput

0.479

High

434650

LTN1
E3 ubiquitin-protein ligase listerin

1

1

Small-scale

0.479

High

434654

NOC4
Nucleolar complex protein 4

1

2

High-throughput

0.479

High

434664

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.479

High

434665

RL7B
Large ribosomal subunit protein uL30B

1

3

High-throughput

0.479

High

434669

RL21B
Large ribosomal subunit protein eL21B

1

2

High-throughput

0.479

High

434670

RL13A
Large ribosomal subunit protein eL13A

1

3

High-throughput

0.479

High

434672

RL11B
Large ribosomal subunit protein uL5B

1

4

High-throughput

0.479

High

383403

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

414969

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.458

High

434206

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

434472

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

434474

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

434482

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

434488

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.458

High

434490

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.458

High

434491

RS30A
Small ribosomal subunit protein eS30A

1

0

High-throughput

0.458

High

434494

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

434499

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

434502

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.458

High

434506

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

434516

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

434523

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

434534

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.458

High

434542

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

434552

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

434558

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

434559

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

434562

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.458

High

434563

LSM12
Protein LSM12

1

0

High-throughput

0.458

High

434565

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.458

High

434583

THO1
Protein THO1

1

0

High-throughput

0.458

High

434594

NOP2
25S rRNA

1

0

Small-scale

0.458

High

434608

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

434615

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.458

High

434621

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

434636

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

434655

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

434660

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

434663

CHS5
Chitin biosynthesis protein CHS5

1

0

High-throughput

0.458

High

434673

RS25A
Small ribosomal subunit protein eS25A

1

0

High-throughput

0.458

High

434585

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

434666

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.439

High

364220

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.437

High

434480

MYO1
Myosin-1

1

2

Small-scale

0.437

High

434515

PWP1
Periodic tryptophan protein 1

1

4

High-throughput

0.437

High

434521

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.437

High

434531

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

434532

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

434536

CHD1
Chromo domain-containing protein 1

1

2

High-throughput

0.437

High

434539

MRT4
Ribosome assembly factor MRT4

1

3

Small-scale

0.437

High

434547

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.437

High

434550

RDH54
DNA repair and recombination protein RDH54

1

2

High-throughput

0.437

High

434557

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.437

High

434560

ECM29
Proteasome component ECM29

1

2

High-throughput

0.437

High

434566

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.437

High

434572

DHH1
ATP-dependent RNA helicase DHH1

1

5

High-throughput

0.437

High

434578

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

1

High-throughput

0.437

High

434597

ELP2
Elongator complex protein 2

1

3

High-throughput

0.437

High

434612

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.437

High

434616

VID30
GID complex subunit 1

1

2

High-throughput

0.437

High

434619

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.437

High

434622

SDA1
Protein SDA1

1

1

High-throughput

0.437

High

434623

H1
Histone H1

1

1

High-throughput

0.437

High

434626

GIS2
Zinc finger protein GIS2

1

2

High-throughput

0.437

High

434631

FAP1
FKBP12-associated protein 1

1

1

High-throughput

0.437

High

434635

NOP3
Serine/arginine

1

1

High-throughput

0.437

High

434638

ABF2
ARS-binding factor 2, mitochondrial

1

4

High-throughput

0.437

High

434643

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.437

High

434645

ARX1
Probable metalloprotease ARX1

1

1

High-throughput

0.437

High

434658

RIX7
Ribosome biogenesis ATPase RIX7

1

3

High-throughput

0.437

High

434517

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

434511

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.407

High

434553

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

2

High-throughput

0.407

High

434569

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.407

High

434587

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.407

High

434599

ERJ5
ER-localized J domain-containing protein 5

1

1

High-throughput

0.407

High

434602

JJJ2
J protein JJJ2

1

2

High-throughput

0.407

High

434662

NOP53
Ribosome biogenesis protein NOP53

1

1

Small-scale

0.407

High

434667

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

434651

RQC1
Ribosome quality control complex subunit 1

3

0

Small-scale

0.334

High

434554

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.305

High

434598

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.305

High

434582

BIM1
Protein BIM1

1

0

High-throughput

0.279

Low

434503

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.261

Low

401803

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

434477

TFS2
Transcription elongation factor S-II

1

0

High-throughput

0.249

Low

434507

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

434508

ACOX
Acyl-coenzyme A oxidase

1

0

High-throughput

0.249

Low

434513

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

434519

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

434538

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

434544

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

434556

RFC1
Replication factor C subunit 1

1

0

High-throughput

0.249

Low

434564

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

0

High-throughput

0.249

Low

434574

ECM1
Shuttling pre-60S factor ECM1

1

0

High-throughput

0.249

Low

434584

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

434588

YIQ1
Uncharacterized protein YIL161W

1

0

High-throughput

0.249

Low

434589

TM108
Protein TMA108

1

0

High-throughput

0.249

Low

434590

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

434592

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

434603

ALB1
Ribosome biogenesis protein ALB1

1

0

High-throughput

0.249

Low

434605

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

434607

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.249

Low

434620

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.249

Low

434630

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

434641

ELP3
Elongator complex protein 3

1

0

High-throughput

0.249

Low

434652

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

High-throughput

0.249

Low

434653

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

434656

PBP4
Protein PBP4

1

0

High-throughput

0.249

Low

434657

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

434659

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

434668

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.249

Low

434671

EFG1P
rRNA-processing protein EFG1

1

0

Small-scale

0.249

Low

434543

LHS1
Heat shock protein 70 homolog LHS1

1

0

High-throughput

0.232

Low

434546

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.232

Low

434570

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low

434571

XDJ1
DnaJ protein homolog XDJ1

1

0

High-throughput

0.232

Low

434580

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low

434604

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

434649

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025