HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: NEK8 (Q86SG6)
Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a)
Gene: NEK8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 692
+	Hs
		684225 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NEK9_HUMAN (3-689): 0: 603: 34.37
+	Hs
		909842 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NEK9_HUMAN (3-689): 0: 603: 34.37
+	Hs
		647836 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK3_HUMAN (3-436): 2.69e-134: 414: 22.60
+	Hs
		683925 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK1_HUMAN (4-457): 4.01e-126: 394: 23.08
+	Mm
		910231 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK3_MOUSE (3-439): 7.71e-135: 416: 23.13
+	Hs
		647862 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK3_HUMAN (3-436): 2.69e-134: 414: 22.60
+	At
		1280891 14337_ARATH (2-247): 4.35e-147: 413: 58.07		CIPKC_ARATH (3-395): 2.73e-131: 398: 21.62
+	Xl
		223344 O57468_XENLA (2-246): 5.73e-145: 407: 60.00		Q804T2_XENLA (3-436): 6.37e-130: 402: 22.83
+	Xl
		223345 O57468_XENLA (2-246): 5.73e-145: 407: 60.00		Q8QGV3_XENLA (3-439): 4.41e-129: 402: 22.27
+	Hs
		909916 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK4_HUMAN (3-436): 6.8e-128: 398: 22.97
+	Mm
		910308 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK4_MOUSE (3-436): 1.16e-126: 395: 22.75
+	Hs
		883214 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SIK1_HUMAN (4-457): 4.01e-126: 394: 23.08
+	Mm
		910234 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK2_MOUSE (3-447): 3.13e-126: 394: 22.64
+	Hs
		909531 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		KCC2G_HUMAN (2-401): 7.59e-121: 373: 23.80
+	Hs
		568616 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		KAPCA_HUMAN (1-308): 1.8e-119: 362: 25.48
+	Hs
		909932 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NEK1_HUMAN (1-255): 1.2e-69: 249: 48.44
+	Hs
		683913 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NEK4_HUMAN (1-313): 5.52e-60: 218: 37.14
+	Hs
		851417 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NEK4_HUMAN (1-313): 5.52e-60: 218: 37.14
+	Hs
		684220 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NEK11_HUMAN (3-265): 6.17e-47: 178: 36.06
+	Hs
		909721 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NEK10_HUMAN (10-290): 3.19e-36: 148: 31.68