HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1332
+	Hs
		909810 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		684386 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324746 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324772 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		684115 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MRCKG_HUMAN (6-1299): 0: 652: 16.34
+	Hs
		684157 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		909730 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Mm
		910234 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK2_MOUSE (8-747): 1.31e-130: 423: 14.66
+	Xl
		223345 O57468_XENLA (2-246): 5.73e-145: 407: 60.00		Q8QGV3_XENLA (2-747): 6.26e-129: 418: 13.86
+	Hs
		683977 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M3K10_HUMAN (21-845): 1.48e-113: 381: 19.26
+	At
		1280891 14337_ARATH (2-247): 4.35e-147: 413: 58.07		CIPKC_ARATH (9-464): 5.99e-128: 405: 21.21
+	Mm
		910231 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK3_MOUSE (16-747): 5.13e-125: 407: 14.31
+	At
		788672 14333_ARATH (3-247): 2.63e-144: 405: 58.30		CIPKC_ARATH (9-464): 5.99e-128: 405: 21.21
+	Mm
		926816 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		SIK3_MOUSE (21-957): 4.22e-126: 425: 12.94
+	At
		965360 14332_ARATH (3-248): 2.23e-144: 405: 58.47		CIPKC_ARATH (9-464): 5.99e-128: 405: 21.21
+	Hs
		909916 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK4_HUMAN (16-739): 9.59e-118: 387: 17.15
+	Hs
		909512 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		STK3_HUMAN (3-507): 3.96e-120: 384: 30.12
+	Mm
		926780 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		MARK3_MOUSE (16-747): 5.13e-125: 407: 14.31
+	Hs
		909462 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K10_HUMAN (21-845): 1.48e-113: 381: 19.26
+	Hs
		909502 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		STK4_HUMAN (5-469): 5.1e-119: 381: 32.99