HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15023544
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1374
+	Hs
		312781 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M3K6_HUMAN (27-1374): 0: 1171: 43.67
+	Hs
		312790 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K6_HUMAN (27-1374): 0: 1171: 43.67
+	Hs
		647836 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK3_HUMAN (625-1374): 2.41e-158: 497: 15.81
+	Hs
		684157 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK2_HUMAN (629-1374): 9.11e-149: 472: 14.03
+	Hs
		647862 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK3_HUMAN (625-1374): 2.41e-158: 497: 15.81
+	Mm
		910231 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK3_MOUSE (654-1374): 5.01e-158: 496: 15.98
+	Hs
		684364 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK1_HUMAN (622-1374): 4.12e-143: 458: 15.27
+	Mm
		910234 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK2_MOUSE (629-1374): 3.1e-151: 478: 13.72
+	Mm
		910318 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK1_MOUSE (622-1374): 6.04e-143: 457: 15.39
+	Hs
		684052 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		KS6A2_HUMAN (673-1074): 1.52e-117: 386: 20.91
+	Hs
		683913 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NEK4_HUMAN (680-1303): 2.63e-113: 378: 19.70
+	Hs
		851417 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NEK4_HUMAN (680-1303): 2.63e-113: 378: 19.70
+	Hs
		684020 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		KCC2D_HUMAN (678-995): 1.4e-97: 324: 26.53
+	At
		1280891 14337_ARATH (2-247): 4.35e-147: 413: 58.07		CIPKC_ARATH (649-982): 3.22e-99: 328: 26.69
+	Hs
		909512 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		STK3_HUMAN (686-1116): 1.95e-98: 326: 25.39
+	Hs
		909502 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		STK4_HUMAN (686-954): 1.73e-97: 323: 33.95
+	Hs
		684413 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M3K2_HUMAN (685-938): 1.31e-41: 165: 40.00
+	Hs
		909513 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		681682 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64
+	Hs
		681770 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64