Protein: YTDC1
YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)

Gene: YTDC1, YTHDC1
Organism: Homo sapiens
Interactions: 192
UniProt ID: Q96MU7

Gene Ontology (top 5):
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0000398 - mRNA splicing, via spliceosome
GO:0001701 - in utero embryonic development
GO:0003723 - RNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889639

CLK2
Dual specificity protein kinase CLK2

5

6

High-throughput

0.725

High

1006636

SRPK2
SRSF protein kinase 2

4

12

High-throughput

0.710

High

965831

HNRPK
Heterogeneous nuclear ribonucleoprotein K

4

14

High-throughput

0.705

High

1219138

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

4

7

High-throughput

0.700

High

1111845

TRA2A
Transformer-2 protein homolog alpha

4

12

High-throughput

0.695

High

284711

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

3

7

High-throughput

0.675

High

1148285

RBY1F
RNA-binding motif protein, Y chromosome, family 1 member F/J

3

13

High-throughput

0.675

High

1398437

SDCB2
Syntenin-2

4

0

High-throughput

0.668

High

472993

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

15

High-throughput

0.667

High

794588

RBMX
RNA-binding motif protein, X chromosome

3

17

High-throughput

0.667

High

1286216

RALYL
RNA-binding Raly-like protein

3

16

High-throughput

0.667

High

1346891

SNIP1
Smad nuclear-interacting protein 1

4

0

High-throughput

0.664

High

1398454

FBW1B
F-box/WD repeat-containing protein 11

3

7

High-throughput

0.662

High

988190

TRA2B
Transformer-2 protein homolog beta

3

17

High-throughput

0.654

High

649395

H1T
Histone H1t

2

6

High-throughput

0.628

High

889794

CLK3
Dual specificity protein kinase CLK3

2

6

High-throughput

0.628

High

1090279

ELAV2
ELAV-like protein 2

2

16

High-throughput

0.628

High

1290657

ZCH18
Zinc finger CCCH domain-containing protein 18

2

3

High-throughput

0.628

High

1314829

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

2

2

High-throughput

0.628

High

1398436

NXF2
Nuclear RNA export factor 2

2

1

High-throughput

0.628

High

1059929

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

7

Small-scale

0.614

High

1089513

ILF2
Interleukin enhancer-binding factor 2

2

1

High-throughput

0.611

High

177294

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

6

High-throughput

0.606

High

515849

RBY1A
RNA-binding motif protein, Y chromosome, family 1 member A1

2

15

High-throughput

0.606

High

1145332

RNPS1
RNA-binding protein with serine-rich domain 1

2

13

High-throughput

0.606

High

1398431

SRPK1
SRSF protein kinase 1

1

11

High-throughput

0.604

High

868377

CDX1
Homeobox protein CDX-1

2

0

High-throughput

0.602

High

658349

RS3
Small ribosomal subunit protein uS3

2

4

High-throughput

0.601

High

1009290

PRR3
Proline-rich protein 3

2

1

High-throughput

0.601

High

1016571

SRSF3
Serine/arginine-rich splicing factor 3

2

15

High-throughput

0.601

High

1062084

SRSF4
Serine/arginine-rich splicing factor 4

2

14

High-throughput

0.601

High

1398442

LN28A
Protein lin-28 homolog A

2

8

High-throughput

0.601

High

1398447

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

2

6

High-throughput

0.601

High

1398456

ZN346
Zinc finger protein 346

2

1

High-throughput

0.601

High

1398461

YBOX2
Y-box-binding protein 2

2

8

High-throughput

0.601

High

242628

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

260321

BRD4
Bromodomain-containing protein 4

2

4

High-throughput

0.584

High

1398444

ANLN
Anillin

2

2

High-throughput

0.584

High

1213583

PHF19
PHD finger protein 19

2

0

High-throughput

0.580

High

1398446

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

480272

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.576

High

396738

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

485345

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

9

High-throughput

0.571

High

894979

EMD
Emerin

1

0

Small-scale

0.549

High

48058

RBM47
RNA-binding protein 47

1

16

High-throughput

0.536

High

74573

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

9

High-throughput

0.536

High

134831

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.536

High

214331

MSI1H
RNA-binding protein Musashi homolog 1

1

14

High-throughput

0.536

High

256670

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

9

High-throughput

0.536

High

272731

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

5

High-throughput

0.536

High

344289

PTBP3
Polypyrimidine tract-binding protein 3

1

11

High-throughput

0.536

High

462575

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

12

High-throughput

0.536

High

478164

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.536

High

807539

IF4A3
Eukaryotic initiation factor 4A-III

1

13

High-throughput

0.536

High

978666

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

1016171

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.536

High

1027673

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

High-throughput

0.536

High

1029731

FOXK2
Forkhead box protein K2

1

2

High-throughput

0.536

High

1051512

SRS11
Serine/arginine-rich splicing factor 11

1

3

High-throughput

0.536

High

1065367

SSRP1
FACT complex subunit SSRP1

1

3

High-throughput

0.536

High

1099483

SRSF6
Serine/arginine-rich splicing factor 6

1

14

High-throughput

0.536

High

1115919

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.536

High

1118129

DX39B
Spliceosome RNA helicase DDX39B

1

11

High-throughput

0.536

High

1148763

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

18

High-throughput

0.536

High

1160047

SRSF7
Serine/arginine-rich splicing factor 7

1

14

High-throughput

0.536

High

1160252

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

14

High-throughput

0.536

High

1168865

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

5

High-throughput

0.536

High

1194295

LARP7
La-related protein 7

1

20

High-throughput

0.536

High

1365650

LAR4B
La-related protein 4B

1

10

High-throughput

0.536

High

1387878

PABP5
Polyadenylate-binding protein 5

1

12

High-throughput

0.536

High

1398445

DDX21
Nucleolar RNA helicase 2

1

9

High-throughput

0.536

High

1398453

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.536

High

1398455

RALY
RNA-binding protein Raly

1

5

High-throughput

0.536

High

1233933

Q6ICH2
single-stranded DNA cytosine deaminase

2

3

High-throughput

0.533

High

765807

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.515

High

1068288

AHNK
Neuroblast differentiation-associated protein AHNAK

1

3

High-throughput

0.515

High

1396716

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

1

High-throughput

0.515

High

192630

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

272989

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

542166

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

574429

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

788153

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

974018

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

1398439

PININ
Pinin

1

0

High-throughput

0.513

High

889484

CLK1
Dual specificity protein kinase CLK1

1

6

High-throughput

0.501

High

609935

SPI1
Transcription factor PU.1

1

0

High-throughput

0.493

High

1191543

TBRG1
Transforming growth factor beta regulator 1

1

0

High-throughput

0.493

High

1380627

FBX32
F-box only protein 32

1

0

High-throughput

0.493

High

1398438

S12A5
Solute carrier family 12 member 5

1

0

High-throughput

0.493

High

1398450

UXT
Protein UXT

1

0

High-throughput

0.493

High

1398457

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

1

High-throughput

0.489

High

273779

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

1

High-throughput

0.481

High

366369

PLMN
Plasminogen

1

3

High-throughput

0.481

High

724418

COR1A
Coronin-1A

1

4

High-throughput

0.481

High

1241488

EDC4
Enhancer of mRNA-decapping protein 4

1

2

High-throughput

0.481

High

1398432

LZTS2
Leucine zipper putative tumor suppressor 2

1

10

High-throughput

0.481

High

1398459

SOX13
Transcription factor SOX-13

1

6

High-throughput

0.481

High

129341

MEN1
Menin

1

2

High-throughput

0.479

High

223263

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

319987

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

362348

ABL1
Tyrosine-protein kinase ABL1

1

2

Small-scale

0.479

High

372871

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

406518

MYCN
N-myc proto-oncogene protein

1

8

High-throughput

0.479

High

414430

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

425602

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.479

High

487644

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.479

High

557431

SRC
Proto-oncogene tyrosine-protein kinase Src

1

4

Small-scale

0.479

High

589444

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

607010

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

696249

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

768925

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

980161

H4
Histone H4

1

3

High-throughput

0.479

High

984914

RL31
Large ribosomal subunit protein eL31

1

3

High-throughput

0.479

High

1004988

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1109197

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

10

High-throughput

0.479

High

1134335

IMB1
Importin subunit beta-1

1

9

High-throughput

0.479

High

1137952

TNIP1
TNFAIP3-interacting protein 1

1

6

High-throughput

0.479

High

1140707

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

1155674

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1161603

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

1215776

RC3H1
Roquin-1

1

9

High-throughput

0.479

High

1235497

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

1276655

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1279887

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

4

High-throughput

0.479

High

1311835

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.479

High

1328911

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

3

High-throughput

0.479

High

1338908

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

1339661

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.479

High

1352695

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1357518

DCAF4
DDB1- and CUL4-associated factor 4

1

4

High-throughput

0.479

High

1367049

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1387499

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

7

High-throughput

0.479

High

1398433

DDX23
Probable ATP-dependent RNA helicase DDX23

1

7

High-throughput

0.479

High

1398434

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

1398435

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

14

High-throughput

0.479

High

1398441

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

1398443

RC3H2
Roquin-2

1

13

High-throughput

0.479

High

1398451

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1398460

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

2

High-throughput

0.479

High

1398440

ATS10
A disintegrin and metalloproteinase with thrombospondin motifs 10

1

1

High-throughput

0.470

High

436975

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.460

High

697224

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

800059

COIL
Coilin

1

0

High-throughput

0.458

High

879371

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

905046

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

961087

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

962389

RHOA
Transforming protein RhoA

1

0

High-throughput

0.458

High

995205

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1017127

H33
Histone H3.3

1

0

High-throughput

0.458

High

1136102

PAF15
PCNA-associated factor

1

0

Small-scale

0.458

High

1137463

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1156821

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1390279

TRI11
E3 ubiquitin-protein ligase TRIM11

1

0

Small-scale

0.458

High

1398463

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

58905

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

809790

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.445

High

860892

RS10
Small ribosomal subunit protein eS10

1

4

High-throughput

0.445

High

977336

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.445

High

1034605

AK17A
A-kinase anchor protein 17A

1

2

High-throughput

0.445

High

1112131

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.445

High

1130393

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.445

High

1203233

ODFP2
Outer dense fiber protein 2

1

4

High-throughput

0.445

High

1337410

SRFB1
Serum response factor-binding protein 1

1

1

High-throughput

0.445

High

1383322

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

3

High-throughput

0.445

High

1398458

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.445

High

1063539

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.439

High

1250758

MPRIP
Myosin phosphatase Rho-interacting protein

1

4

High-throughput

0.439

High

272394

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

294194

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1227280

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

1255118

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1310865

LMTK2
Serine/threonine-protein kinase LMTK2

1

7

High-throughput

0.437

High

1325512

FBXW8
F-box/WD repeat-containing protein 8

1

10

High-throughput

0.437

High

1351945

RBCC1
RB1-inducible coiled-coil protein 1

1

10

High-throughput

0.437

High

1389350

RNF31
E3 ubiquitin-protein ligase RNF31

1

5

High-throughput

0.437

High

1398449

SLAI2
SLAIN motif-containing protein 2

1

1

High-throughput

0.437

High

1119258

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1390957

THOC1
THO complex subunit 1

1

0

Small-scale

0.426

High

1398430

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

1398462

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.426

High

73439

B2CML4
single-stranded DNA cytosine deaminase

1

3

High-throughput

0.407

High

1371410

DVL3
Segment polarity protein dishevelled homolog DVL-3

3

0

High-throughput

0.352

High

1256718

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

950198

KR106
Keratin-associated protein 10-6

2

0

High-throughput

0.316

High

391411

FRIL
Ferritin light chain

2

0

High-throughput

0.313

High

350621

TXD12
Thioredoxin domain-containing protein 12

1

0

High-throughput

0.269

Low

219220

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.251

Low

472346

CFAH
Complement factor H

1

0

High-throughput

0.251

Low

1292667

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.251

Low

1398448

SEP10
Septin-10

1

0

High-throughput

0.251

Low

1398452

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.251

Low

1398464

LAMC3
Laminin subunit gamma-3

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025