HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	23752268, 15923258
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1122
+	Mm
		250870 1433S_MOUSE (1-248): 4.84e-154: 429: 97.58		Q3UJF1_MOUSE (1-1122): 0: 717: 92.71
+	Mm
		250879 1433S_MOUSE (1-248): 4.84e-154: 429: 97.58		HDAC5_MOUSE (1-1122): 0: 713: 92.17
+	Hs
		910173 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Mm
		910239 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		Q3UJF1_MOUSE (1-1122): 0: 717: 92.71
+	Mm
		910352 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		HDAC5_MOUSE (1-1122): 0: 713: 92.17
+	Hs
		683923 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		880661 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		684387 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		HDAC9_HUMAN (25-1055): 0: 608: 56.33
+	Hs
		880673 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		910144 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HDAC9_HUMAN (25-1055): 0: 608: 56.33
+	Hs
		684233 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		909856 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		927340 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		909530 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Mm
		910299 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		HDAC7_MOUSE (191-1122): 3.04e-139: 446: 37.55
+	Hs
		927372 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		177251 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	At
		817061 14310_ARATH (2-247): 2.9e-137: 387: 53.63		HDA5_ARATH (678-1110): 1.04e-142: 446: 34.38
+	Hs
		910121 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Hs
		927619 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97