HitPredict

Interactor 1: PRDX2 (P32119)
Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2)
Gene: PRDX2

Interactor 2: BIRC3 (Q13489)
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
Gene: BIRC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30948266
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042981 - regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 198 Hs			1 604
+	Hs
		670942 PRDX3_HUMAN (2-198): 8.33e-101: 293: 63.45		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		989282 PRDX1_HUMAN (1-197): 7.49e-100: 288: 77.78		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		1026673 PRDX4_HUMAN (5-198): 2.62e-96: 282: 70.10		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		670943 PRDX3_HUMAN (2-198): 8.33e-101: 293: 63.45		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		670701 PRDX6_HUMAN (4-196): 1.88e-67: 207: 29.13		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		685665 PRDX2_HUMAN (1-198): 3.46e-104: 299: 100.00		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		670929 PRDX3_HUMAN (2-198): 8.33e-101: 293: 63.45		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Dm
		1097117 PRDX2_DROME (5-195): 6.74e-95: 276: 70.16		DIAP2_DROME (9-100): 4.66e-25: 110: 31.52
+	Dm
		1097118 Q9V3Q4_DROME (1-198): 3.04e-94: 276: 67.68		DIAP2_DROME (9-100): 4.66e-25: 110: 31.52
+	Dm
		1097059 Q9V3Q4_DROME (1-198): 3.04e-94: 276: 67.68		DIAP1_DROME (20-173): 1.43e-24: 108: 24.36