Interactor 1: CNTF (P26441)
Ciliary neurotrophic factor (CNTF)
Gene: CNTF

Interactor 2: LIFR (P42702)
Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)
Gene: LIFR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.853

The method score is based on:

Property Details
Experiments 10207005, 18775332, 16051226
Identification Methods coimmunoprecipitation, isothermal titration calorimetry, molecular sieving, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CNTF~fn3, CNTF~LIF-R_Ig-like
Common GO terms GO:0005127 - ciliary neurotrophic factor receptor binding
GO:0008284 - positive regulation of cell population proliferation
GO:0070120 - ciliary neurotrophic factor-mediated signaling pathway
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 200
Hs

1 1097
+ Mm
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025