Protein: IL6RB
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)

Gene: IL6RB, IL6ST
Organism: Homo sapiens
Interactions: 75
UniProt ID: P40189

Gene Ontology (top 5):
GO:0002675 - positive regulation of acute inflammatory response
GO:0002821 - positive regulation of adaptive immune response
GO:0004896 - cytokine receptor activity
GO:0004897 - ciliary neurotrophic factor receptor activity
GO:0004921 - interleukin-11 receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

567757

ONCM
Oncostatin-M

6

4

Small-scale

0.943

High

477100

IL6RA
Interleukin-6 receptor subunit alpha

6

15

Small-scale

0.932

High

820531

PTN11
Tyrosine-protein phosphatase non-receptor type 11

5

18

Small-scale

0.909

High

658647

JAK1
Tyrosine-protein kinase JAK1

4

20

Small-scale

0.907

High

155917

SOCS3
Suppressor of cytokine signaling 3

4

20

Small-scale

0.893

High

426977

IL6
Interleukin-6

3

1

Small-scale

0.845

High

820513

IL6RB
Interleukin-6 receptor subunit beta

3

15

Small-scale

0.827

High

578201

LIF
Leukemia inhibitory factor

2

2

Small-scale

0.778

High

375252

RASK
GTPase KRas

2

20

High-throughput

0.754

High

820514

STAT3
Signal transducer and activator of transcription 3

2

8

Small-scale

0.754

High

820516

LIFR
Leukemia inhibitory factor receptor

2

16

Small-scale

0.754

High

820541

OSMR
Oncostatin-M-specific receptor subunit beta

2

16

Small-scale

0.754

High

820526

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.747

High

689982

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

1

17

Small-scale

0.724

High

711265

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.724

High

635106

IL11
Interleukin-11

2

1

Small-scale

0.713

High

820538

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

4

5

High-throughput

0.683

High

584486

VAV
Proto-oncogene vav

1

15

Small-scale

0.681

High

714581

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.665

High

820548

CSEN
Calsenilin

3

2

High-throughput

0.660

High

686741

CNTF
Ciliary neurotrophic factor

1

5

Small-scale

0.647

High

820519

CDK9
Cyclin-dependent kinase 9

1

7

Small-scale

0.647

High

820529

TLE1
Transducin-like enhancer protein 1

1

5

Small-scale

0.637

High

820547

UBQL1
Ubiquilin-1

1

5

High-throughput

0.621

High

253315

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

362899

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

373811

RASN
GTPase NRas

1

20

High-throughput

0.618

High

410678

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

466134

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

473376

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

519805

ANDR
Androgen receptor

1

5

Small-scale

0.618

High

580907

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601195

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

641504

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

Small-scale

0.618

High

699622

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

7

Small-scale

0.618

High

711047

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

18

Small-scale

0.618

High

774188

BASI
Basigin

1

18

High-throughput

0.618

High

820517

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.618

High

820520

RAB25
Ras-related protein Rab-25

1

6

High-throughput

0.618

High

820521

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

820522

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

820523

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

820524

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.618

High

820525

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

820527

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

820528

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

820530

KPCD
Protein kinase C delta type

1

2

Small-scale

0.618

High

820543

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

820545

FBX2
F-box only protein 2

3

15

Small-scale

0.612

High

226719

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

6

High-throughput

0.606

High

820544

KCIP1
A-type potassium channel modulatory protein KCNIP1

2

2

High-throughput

0.606

High

480733

LEG1
Galectin-1

2

20

High-throughput

0.601

High

820518

MAGAB
Melanoma-associated antigen 11

3

5

High-throughput

0.597

High

820533

I11RA
Interleukin-11 receptor subunit alpha

2

17

Small-scale

0.584

High

820540

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

Small-scale

0.578

High

139185

UPK2
Uroplakin-2

2

0

High-throughput

0.576

High

820515

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

7

Small-scale

0.575

High

170687

CLGN
Calmegin

2

7

High-throughput

0.549

High

328638

VAMP5
Vesicle-associated membrane protein 5

1

1

High-throughput

0.536

High

820542

TMPSD
Transmembrane protease serine 13

1

6

High-throughput

0.536

High

820546

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.536

High

820549

ST14
Suppressor of tumorigenicity 14 protein

1

6

High-throughput

0.536

High

378612

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.513

High

820535

PARM1
Prostate androgen-regulated mucin-like protein 1

1

0

High-throughput

0.513

High

820537

CMYA5
Cardiomyopathy-associated protein 5

1

20

High-throughput

0.494

High

136667

TRAF5
TNF receptor-associated factor 5

1

6

Small-scale

0.479

High

217914

TGON2
Trans-Golgi network integral membrane protein 2

1

14

High-throughput

0.479

High

555923

CADH1
Cadherin-1

1

13

High-throughput

0.479

High

254860

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

13

High-throughput

0.445

High

609612

LEG3
Galectin-3

1

20

High-throughput

0.445

High

820532

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

13

High-throughput

0.445

High

820536

NIPA1
Magnesium transporter NIPA1

1

5

High-throughput

0.445

High

820534

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.437

High

820539

ZDH15
Palmitoyltransferase ZDHHC15

1

5

Small-scale

0.437

High


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Last updated: 11Aug2025