HitPredict

Interactor 1: MK03 (P27361)
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
Gene: MAPK3

Interactor 2: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

The method score is based on:

Property	Details
Experiments	17189385, 33438746
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006351 - DNA-templated transcription and 6 others more... GO:0035556 - intracellular signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070498 - interleukin-1-mediated signaling pathway GO:0071356 - cellular response to tumor necrosis factor GO:0098978 - glutamatergic synapse GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	379
Hs

1	551

Service provided by Combinatics, Japan

Last updated: 11Aug2025