HitPredict

Interactor 1: GSP1 (P32835)
GTP-binding nuclear protein GSP1/CNR1 (Chromosome stability protein 17) (GTPase Ran homolog) (Genetic suppressor of PRP20-1)
Gene: GSP1

Interactor 2: KA120 (Q02932)
Importin beta-like protein KAP120 (Karyopherin-120)
Gene: KAP120

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.922

Property	Details
Experiments	16581791, 18719252, 15679097, 34646016, 21329658
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IBN_N~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 219 Sc			1 1032
+	Sc
		699016 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		KA120_YEAST (1-1032): 0: 588: 100.00
+	Hs
		312234 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO7_HUMAN (5-1028): 6.28e-172: 532: 13.17
+	Hs
		874484 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO2_HUMAN (3-1027): 2.72e-168: 521: 14.65
+	Hs
		178143 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO8_HUMAN (5-1026): 1.37e-165: 516: 13.35
+	Dm
		1373317 RANL_DROME (13-219): 2.1e-90: 266: 59.42		Q9VRV8_DROME (1-937): 8.47e-149: 467: 10.50
+	Hs
		919198 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO1_HUMAN (3-937): 2.63e-160: 497: 11.57
+	Hs
		155560 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO2_HUMAN (1-967): 3.84e-154: 481: 11.62
+	At
		784988 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		TNPO1_ARATH (4-947): 1.24e-128: 414: 10.01
+	Hs
		919299 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO11_HUMAN (5-1024): 2.63e-144: 458: 24.57
+	Sp
		142272 SPI1_SCHPO (5-219): 6.33e-77: 232: 88.37		CSE1_SCHPO (17-1022): 4.07e-123: 401: 14.42
+	Sc
		698750 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		CSE1_YEAST (8-1024): 3.17e-111: 369: 14.42
+	Sc
		698999 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		CSE1_YEAST (8-1024): 3.17e-111: 369: 14.42
+	Sc
		698861 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		NMD5_YEAST (8-1024): 3.86e-106: 357: 11.85
+	Hs
		162599 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO1_HUMAN (4-907): 1.73e-103: 350: 10.91
+	Hs
		919222 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO9_HUMAN (11-924): 2.58e-100: 341: 13.18
+	Sc
		698930 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		SXM1_YEAST (11-1028): 2.07e-94: 323: 14.34
+	Sc
		698878 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		IMB5_YEAST (11-918): 1.36e-89: 311: 12.23
+	At
		784992 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		IMB1_ARATH (11-701): 5.49e-26: 117: 13.73
+	At
		784999 RAN2_ARATH (1-216): 1.74e-88: 261: 75.58		IMB1_ARATH (11-701): 5.49e-26: 117: 13.73
+	At
		1210454 RAN3_ARATH (1-219): 5.37e-84: 250: 74.55		IMB1_ARATH (11-701): 5.49e-26: 117: 13.73