HitPredict

Interactor 1: STX2 (P32856)
Syntaxin-2 (Epimorphin)
Gene: STX2

Interactor 2: VAMP3 (Q15836)
Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)
Gene: VAMP3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	12828989, 32296183, unassigned1304, 24373201
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005886 - plasma membrane GO:0006887 - exocytosis GO:0031201 - SNARE complex GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 100
+	Hs
		620262 STX1B_HUMAN (1-287): 6.03e-81: 247: 64.81		VAMP1_HUMAN (8-87): 1.27e-25: 93.9: 80.00
+	Hs
		699254 STX2_HUMAN (1-288): 5.69e-82: 250: 100.00		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Rn
		699182 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		VAMP1_RAT (8-99): 1.05e-26: 96.6: 72.83
+	Hs
		699284 STX2_HUMAN (1-288): 5.69e-82: 250: 100.00		VAMP8_HUMAN (6-82): 1.84e-22: 85: 35.07
+	Hs
		263179 STX2_HUMAN (1-288): 5.69e-82: 250: 100.00		SC22B_HUMAN (8-97): 4.57e-21: 84.7: 25.56
+	Mm
		898816 STX1B_MOUSE (1-287): 6.03e-81: 247: 64.81		VAMP2_MOUSE (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		898830 STX1B_HUMAN (1-287): 6.03e-81: 247: 64.81		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		306763 STX2_HUMAN (1-288): 5.69e-82: 250: 100.00		VAMP5_HUMAN (11-80): 1.96e-20: 80.4: 38.57
+	Rn
		699183 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		VAMP7_RAT (7-80): 2.77e-23: 90.4: 35.14
+	Hs
		620271 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP1_HUMAN (8-87): 1.27e-25: 93.9: 80.00
+	Hs
		261664 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP4_HUMAN (3-82): 3.5e-25: 93.5: 40.00
+	Hs
		306784 STX1B_HUMAN (1-287): 6.03e-81: 247: 64.81		VAMP5_HUMAN (11-80): 1.96e-20: 80.4: 38.57
+	Mm
		192845 STX1A_MOUSE (1-287): 5.2e-78: 240: 65.63		VAMP2_MOUSE (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		850569 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP7_HUMAN (7-79): 4.38e-23: 90: 31.51
+	Rn
		699175 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		VAMP2_RAT (8-84): 1.68e-22: 85.8: 87.01
+	Mm
		139056 STX1A_MOUSE (1-287): 5.2e-78: 240: 65.63		SC22B_MOUSE (8-97): 4.57e-21: 84.7: 25.56
+	Rn
		699186 STX1A_RAT (1-287): 7.28e-78: 239: 65.28		VAMP8_RAT (6-78): 2.53e-22: 84.6: 35.62
+	Hs
		926213 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP2_HUMAN (8-84): 1.68e-22: 85.8: 87.01
+	Hs
		263248 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		SC22B_HUMAN (8-97): 4.57e-21: 84.7: 25.56
+	Hs
		306800 STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46		VAMP5_HUMAN (11-80): 1.96e-20: 80.4: 38.57