HitPredict

Interactor 1: TTK (P33981)
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
Gene: TTK

Interactor 2: CCNF (P41002)
Cyclin-F (F-box only protein 1)
Gene: CCNF

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36114006
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 857 Hs			1 786
+	Hs
		779490 PKN1_HUMAN (49-854): 5.4e-155: 480: 13.90		CCNF_HUMAN (1-786): 0: 952: 100.00
+	Hs
		779491 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		CCNF_HUMAN (1-786): 0: 952: 100.00
+	Hs
		779613 PKN3_HUMAN (49-854): 3.01e-144: 450: 14.95		CCNF_HUMAN (1-786): 0: 952: 100.00
+	Hs
		682145 AKT2_HUMAN (411-841): 5.63e-119: 371: 17.58		CCNF_HUMAN (1-786): 0: 952: 100.00
+	Hs
		779370 KCC2D_HUMAN (519-856): 1.32e-113: 357: 22.95		CCNF_HUMAN (1-786): 0: 952: 100.00
+	Hs
		779057 KS6A3_HUMAN (477-818): 6.94e-81: 277: 21.05		CCNF_HUMAN (1-786): 0: 952: 100.00
+	Hs
		780416 M3K4_HUMAN (530-795): 2.19e-22: 105: 27.47		CCNF_HUMAN (1-786): 0: 952: 100.00
+	Hs
		779248 CDK5_HUMAN (525-790): 5.66e-20: 93.2: 27.70		CCNF_HUMAN (1-786): 0: 952: 100.00
+	Hs
		538556 PKN2_HUMAN (49-854): 1e-151: 472: 14.24		CCNB1_HUMAN (130-537): 8.12e-120: 369: 19.00
+	Hs
		590134 AKT2_HUMAN (411-841): 5.63e-119: 371: 17.58		CCNA2_HUMAN (141-536): 3.28e-99: 315: 22.28
+	Hs
		590239 AKT3_HUMAN (468-857): 3.46e-119: 371: 18.05		CCNA2_HUMAN (141-536): 3.28e-99: 315: 22.28
+	Hs
		538522 CDK5_HUMAN (525-790): 5.66e-20: 93.2: 27.70		CCNB1_HUMAN (130-537): 8.12e-120: 369: 19.00
+	Hs
		303843 CDK5_HUMAN (525-790): 5.66e-20: 93.2: 27.70		CCNB2_HUMAN (153-537): 5.16e-112: 347: 17.77
+	Hs
		590164 CDK5_HUMAN (525-790): 5.66e-20: 93.2: 27.70		CCNA2_HUMAN (141-536): 3.28e-99: 315: 22.28
+	Hs
		624597 KKCC1_HUMAN (565-791): 3.35e-20: 97.1: 32.47		CCNE1_HUMAN (177-567): 1.06e-93: 300: 16.14
+	Sc
		339459 CDK1_YEAST (525-792): 4.28e-21: 96.7: 29.37		CG23_YEAST (280-528): 4.92e-93: 299: 23.62
+	Hs
		624575 CDK5_HUMAN (525-790): 5.66e-20: 93.2: 27.70		CCNE1_HUMAN (177-567): 1.06e-93: 300: 16.14
+	Sc
		339460 CDK1_YEAST (525-792): 4.28e-21: 96.7: 29.37		CG24_YEAST (310-532): 4.48e-17: 86.7: 25.78