Protein: LRP8
Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)

Gene: LRP8
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q14114

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001540 - amyloid-beta binding
GO:0004888 - transmembrane signaling receptor activity
GO:0005041 - low-density lipoprotein particle receptor activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

674662

AMRP
Alpha-2-macroglobulin receptor-associated protein

6

10

Small-scale

0.947

High

944167

RELN
Reelin

8

4

Small-scale

0.747

High

957520

VLDLR
Very low-density lipoprotein receptor

1

9

Small-scale

0.724

High

1048435

LRP8
Low-density lipoprotein receptor-related protein 8

1

9

Small-scale

0.724

High

361485

APOE
Apolipoprotein E

3

7

Small-scale

0.674

High

269145

DAB1
Disabled homolog 1

3

20

Small-scale

0.650

High

1048436

SNX17
Sorting nexin-17

2

4

Small-scale

0.646

High

362634

APOH
Beta-2-glycoprotein 1

1

6

Small-scale

0.618

High

441734

CFAH
Complement factor H

1

9

Small-scale

0.618

High

1032902

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

20

Small-scale

0.594

High

1048463

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

20

Small-scale

0.594

High

942339

DLG4
Disks large homolog 4

2

8

Small-scale

0.586

High

205379

TGON2
Trans-Golgi network integral membrane protein 2

2

8

High-throughput

0.584

High

591845

RAB4A
Ras-related protein Rab-4A

2

9

High-throughput

0.584

High

970699

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

12

Small-scale

0.561

High

1048442

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.553

High

626126

APC
Adenomatous polyposis coli protein

1

1

Small-scale

0.536

High

363790

ALBU
Albumin

1

1

High-throughput

0.536

High

1048461

NEB1
Neurabin-1

1

19

High-throughput

0.536

High

914062

RB11A
Ras-related protein Rab-11A

2

4

High-throughput

0.533

High

111175

I6L9F6
NEFL protein

1

1

High-throughput

0.515

High

717074

CTNB1
Catenin beta-1

1

3

High-throughput

0.515

High

822261

KC1D
Casein kinase I isoform delta

1

4

High-throughput

0.515

High

987510

APLP2
Amyloid beta precursor like protein 2

1

12

High-throughput

0.515

High

1048449

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.515

High

1048460

GGA1
ADP-ribosylation factor-binding protein GGA1

1

3

High-throughput

0.515

High

1048445

GHDC
GH3 domain-containing protein

1

0

High-throughput

0.513

High

1048454

RHG39
Rho GTPase-activating protein 39

1

0

High-throughput

0.513

High

600962

MK
Midkine

1

5

Small-scale

0.501

High

957177

DAB2
Disabled homolog 2

1

20

Small-scale

0.501

High

1048451

NECA3
N-terminal EF-hand calcium-binding protein 3

1

0

High-throughput

0.493

High

1048438

ANGE2
Protein angel homolog 2

1

1

High-throughput

0.489

High

1048441

CRTC3
CREB-regulated transcription coactivator 3

1

1

High-throughput

0.489

High

152740

ITBP1
Integrin beta-1-binding protein 1

1

2

Small-scale

0.481

High

158186

GIPC1
PDZ domain-containing protein GIPC1

1

3

Small-scale

0.481

High

253558

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

20

Small-scale

0.481

High

883911

SYJ2B
Synaptojanin-2-binding protein

1

18

Small-scale

0.481

High

1048453

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

12

Small-scale

0.481

High

1048456

SCN3A
Sodium channel protein type 3 subunit alpha

1

3

Small-scale

0.481

High

120916

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

Small-scale

0.479

High

178529

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

338413

EGFR
Epidermal growth factor receptor

1

15

High-throughput

0.479

High

348658

RASN
GTPase NRas

1

12

High-throughput

0.479

High

350161

RASK
GTPase KRas

1

12

High-throughput

0.479

High

394702

A4
Amyloid-beta precursor protein

1

12

Small-scale

0.479

High

527448

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.479

High

591565

RAB3B
Ras-related protein Rab-3B

1

4

High-throughput

0.479

High

592246

RAB5A
Ras-related protein Rab-5A

1

8

High-throughput

0.479

High

669171

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

4

High-throughput

0.479

High

729656

VGFR2
Vascular endothelial growth factor receptor 2

1

5

Small-scale

0.479

High

844515

RAB5C
Ras-related protein Rab-5C

1

8

High-throughput

0.479

High

844918

RAB7A
Ras-related protein Rab-7a

1

9

High-throughput

0.479

High

845474

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.479

High

850040

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

884485

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.479

High

915669

RHOB
Rho-related GTP-binding protein RhoB

1

13

High-throughput

0.479

High

974811

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

984261

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

4

Small-scale

0.479

High

1041542

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1048440

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1048458

ANFY1
Rabankyrin-5

1

2

High-throughput

0.479

High

1048464

LAMP3
Lysosome-associated membrane glycoprotein 3

1

4

High-throughput

0.479

High

495524

THIO
Thioredoxin

1

3

High-throughput

0.470

High

1048452

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

2

High-throughput

0.470

High

912895

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1048437

SSXT
Protein SSXT

1

0

High-throughput

0.458

High

92591

E9PM19
Tyrosine-protein kinase

1

4

High-throughput

0.445

High

103669

G5E9A6
Ubiquitin carboxyl-terminal hydrolase

1

3

High-throughput

0.445

High

1048462

APC10
Anaphase-promoting complex subunit 10

1

3

Small-scale

0.439

High

895074

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.437

High

1048055

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

Small-scale

0.437

High

1048439

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

1048443

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

1048447

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

3

Small-scale

0.408

High

988071

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.279

Low

1048446

CS047
Uncharacterized protein C19orf47

1

0

High-throughput

0.279

Low

1048448

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.279

Low

1048450

DOCK6
Dedicator of cytokinesis protein 6

1

0

High-throughput

0.279

Low

1048455

PKRI1
PRKR-interacting protein 1

1

0

High-throughput

0.279

Low

1048457

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

0

High-throughput

0.279

Low

409068

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.269

Low

1048459

CRCT1
Cysteine-rich C-terminal protein 1

1

0

High-throughput

0.268

Low

1048444

DEN6A
Protein DENND6A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024