HitPredict

Interactor 1: MCM4 (P33991)
DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
Gene: MCM4

Interactor 2: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 863 Hs			1 140
+	Hs
		708415 MCM4_HUMAN (1-863): 0: 952: 100.00		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		708421 MCM4_HUMAN (1-863): 0: 952: 100.00		H33_HUMAN (5-134): 1.57e-51: 161: 49.62
+	Hs
		828172 MCM2_HUMAN (2-839): 0: 762: 27.95		CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00
+	Hs
		832357 MCM2_HUMAN (2-839): 0: 762: 27.95		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		832495 MCM2_HUMAN (2-839): 0: 762: 27.95		H31T_HUMAN (5-134): 1.01e-51: 162: 48.09
+	Hs
		832369 MCM2_HUMAN (2-839): 0: 762: 27.95		H33_HUMAN (5-134): 1.57e-51: 161: 49.62
+	Hs
		832541 MCM2_HUMAN (2-839): 0: 762: 27.95		H32_HUMAN (5-134): 1.73e-51: 161: 48.86
+	Mm
		935446 MCM2_MOUSE (4-839): 0: 751: 27.67		H31_MOUSE (5-134): 1.29e-52: 164: 48.86
+	Mm
		952250 MCM2_MOUSE (4-839): 0: 751: 27.67		H32_MOUSE (5-134): 1.73e-51: 161: 48.86
+	Mm
		952736 MCM2_MOUSE (4-839): 0: 751: 27.67		H33_MOUSE (5-134): 1.57e-51: 161: 49.62
+	Sc
		675521 MCM4_YEAST (1-862): 0: 745: 41.83		CENPA_YEAST (24-134): 1.24e-44: 147: 45.54
+	Sc
		675545 MCM4_YEAST (1-862): 0: 745: 41.83		H3_YEAST (5-134): 5.26e-46: 147: 46.57
+	Hs
		708603 MCM5_HUMAN (133-846): 0: 698: 30.23		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		708661 MCM5_HUMAN (133-846): 0: 698: 30.23		H31T_HUMAN (5-134): 1.01e-51: 162: 48.09
+	Hs
		708683 MCM5_HUMAN (133-846): 0: 698: 30.23		H3C_HUMAN (5-134): 5.15e-52: 162: 47.69
+	Hs
		708605 MCM5_HUMAN (133-846): 0: 698: 30.23		H33_HUMAN (5-134): 1.57e-51: 161: 49.62
+	Hs
		708690 MCM5_HUMAN (133-846): 0: 698: 30.23		H32_HUMAN (5-134): 1.73e-51: 161: 48.86
+	Hs
		708677 MCM5_HUMAN (133-846): 0: 698: 30.23		H37_HUMAN (5-134): 1.18e-49: 156: 47.33
+	Sc
		667566 MCM2_YEAST (4-784): 0: 688: 26.05		CENPA_YEAST (24-134): 1.24e-44: 147: 45.54
+	Sc
		667617 MCM2_YEAST (4-784): 0: 688: 26.05		H3_YEAST (5-134): 5.26e-46: 147: 46.57