HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 33961781, 21875946
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0004672 - protein kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007411 - axon guidance
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 607
Hs

1 986
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024