HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: DSC3 (Q14574)
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Gene: DSC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	35384245, 21875946
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 607 Hs			1 896
+	Hs
		508000 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		DSC3_HUMAN (1-896): 0: 847: 100.00
+	Hs
		1055826 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		DSC3_HUMAN (1-896): 0: 847: 100.00
+	Hs
		713898 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDG6_HUMAN (1-818): 0: 732: 18.48
+	Hs
		713896 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDGH_HUMAN (2-464): 7.18e-93: 315: 15.98
+	Hs
		508295 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		PCDA8_HUMAN (2-470): 1.82e-86: 298: 16.16
+	Hs
		231356 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDGC_HUMAN (2-464): 1.15e-84: 292: 18.41
+	Hs
		508294 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		PCDB7_HUMAN (2-485): 5.59e-82: 282: 17.26
+	Hs
		713899 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDG5_HUMAN (2-464): 1.03e-81: 284: 17.86
+	Hs
		713894 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCDB2_HUMAN (2-475): 1.39e-77: 270: 16.36
+	Hs
		507842 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55
+	Hs
		580205 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55
+	Hs
		580237 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55
+	Hs
		507929 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		CAD11_HUMAN (4-349): 7.96e-40: 160: 18.98
+	Hs
		507817 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		CADH1_HUMAN (2-464): 1.66e-38: 157: 15.98
+	Xl
		292719 FGFR1_XENLA (137-601): 2.66e-139: 426: 26.10		O93264_XENLA (4-345): 1.61e-41: 165: 17.36
+	Hs
		713831 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		DSG4_HUMAN (2-468): 3.08e-30: 130: 14.48
+	Hs
		713786 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		DSC2_HUMAN (3-350): 7.18e-27: 120: 13.83
+	Hs
		507992 FGFR1_HUMAN (137-599): 4.53e-145: 441: 27.29		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		713802 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85
+	Hs
		1048593 NTRK3_HUMAN (61-607): 7.76e-137: 420: 21.92		DSG2_HUMAN (69-391): 3.52e-20: 98.5: 17.85