HitPredict

Interactor 1: RYK (P34925)
Tyrosine-protein kinase RYK (EC 2.7.10.1)
Gene: RYK

Interactor 2: CSPG4 (Q6UVK1)
Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan)
Gene: CSPG4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0015026 - coreceptor activity GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 607 Hs			1 2322
+	Hs
		609365 FGFR3_HUMAN (137-601): 1.51e-144: 440: 27.04		CSPG4_HUMAN (1-2322): 0: 1472: 100.00
+	Hs
		713820 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		FREM2_HUMAN (368-2222): 0: 789: 20.15
+	Hs
		713862 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		PCD16_HUMAN (1482-2300): 9.61e-82: 303: 12.08
+	Hs
		713873 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CELR2_HUMAN (1832-2274): 9.62e-50: 198: 11.51
+	Hs
		713881 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CELR3_HUMAN (169-549): 6.33e-43: 176: 14.35
+	Hs
		713850 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		FAT3_HUMAN (3-188): 1.08e-34: 148: 16.11
+	Hs
		713825 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		FAT4_HUMAN (2-205): 2.08e-19: 98.5: 12.50
+	Hs
		523158 SRC_HUMAN (315-602): 2.06e-108: 338: 30.80		CELR2_HUMAN (1832-2274): 9.62e-50: 198: 11.51
+	Hs
		713880 RYK_HUMAN (1-607): 1.73e-146: 438: 100.00		CELR1_HUMAN (2-213): 1.02e-13: 79.6: 14.40
+	Hs
		411385 INSR_HUMAN (237-598): 1.43e-108: 357: 29.40		FAT1_HUMAN (1705-2285): 6.11e-27: 123: 11.77
+	Mm
		555050 MET_MOUSE (330-593): 4.01e-59: 216: 39.47		CELR2_MOUSE (1832-2274): 1.99e-50: 200: 11.09
+	Mm
		555022 MET_MOUSE (330-593): 4.01e-59: 216: 39.47		FAT3_MOUSE (3-213): 4.18e-33: 143: 15.45
+	Mm
		93787 MET_MOUSE (330-593): 4.01e-59: 216: 39.47		E9QK16_MOUSE (3-213): 4.18e-33: 143: 15.45
+	Hs
		441504 MET_HUMAN (265-593): 1.87e-59: 217: 35.95		FAT1_HUMAN (1705-2285): 6.11e-27: 123: 11.77