Protein: HACL2
2-hydroxyacyl-CoA lyase 2 (EC 4.1.2.-) (Acetolactate synthase-like protein) (IlvB-like protein)

Gene: HACL2, ILVBL
Organism: Homo sapiens
Interactions: 233
UniProt ID: A1L0T0

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001561 - fatty acid alpha-oxidation
GO:0003984 - acetolactate synthase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005948 - acetolactate synthase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

50251

GBA2
Non-lysosomal glucosylceramidase

3

0

High-throughput

0.646

High

50234

OSBL6
Oxysterol-binding protein-related protein 6

2

2

High-throughput

0.628

High

50244

OSBL3
Oxysterol-binding protein-related protein 3

2

2

High-throughput

0.628

High

50141

CUL3
Cullin-3

2

3

High-throughput

0.611

High

50140

ILK
Integrin-linked protein kinase

2

0

High-throughput

0.602

High

50187

INT1
Integrator complex subunit 1

2

0

High-throughput

0.602

High

50226

MMS19
MMS19 nucleotide excision repair protein homolog

2

0

High-throughput

0.585

High

50055

ZW10
Centromere/kinetochore protein zw10 homolog

2

0

High-throughput

0.576

High

50137

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

5

High-throughput

0.574

High

50236

XPO4
Exportin-4

2

2

High-throughput

0.574

High

48165

ESYT2
Extended synaptotagmin-2

2

2

High-throughput

0.571

High

50074

EGFR
Epidermal growth factor receptor

2

3

High-throughput

0.571

High

50076

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

50078

NTRK1
High affinity nerve growth factor receptor

2

2

High-throughput

0.543

High

50061

TOM1
Target of Myb1 membrane trafficking protein

1

1

High-throughput

0.541

High

50084

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.541

High

50051

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

3

High-throughput

0.536

High

50100

COPB2
Coatomer subunit beta'

1

4

High-throughput

0.536

High

50105

MTOR
Serine/threonine-protein kinase mTOR

1

4

High-throughput

0.536

High

50119

COPA
Coatomer subunit alpha

1

4

High-throughput

0.536

High

50120

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

50122

TPTE
Putative tyrosine-protein phosphatase TPTE

1

1

High-throughput

0.536

High

50166

TBC9B
TBC1 domain family member 9B

1

2

High-throughput

0.536

High

50179

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

2

High-throughput

0.536

High

50197

COQ8A
Atypical kinase COQ8A, mitochondrial

1

2

High-throughput

0.536

High

50204

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.536

High

50246

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.536

High

50256

MDN1
Midasin

1

1

High-throughput

0.536

High

50265

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.536

High

50060

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.533

High

50049

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

50050

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

50086

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.513

High

50107

GRK6
G protein-coupled receptor kinase 6

1

0

High-throughput

0.513

High

50108

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

High-throughput

0.513

High

50117

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

50123

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

50143

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

50153

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.513

High

50162

PIGG
GPI ethanolamine phosphate transferase 2

1

0

High-throughput

0.513

High

50164

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.513

High

50183

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.513

High

50216

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.513

High

50238

INT2
Integrator complex subunit 2

1

0

High-throughput

0.513

High

50242

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.513

High

50247

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

50268

COG5
Conserved oligomeric Golgi complex subunit 5

1

0

High-throughput

0.513

High

50077

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.500

High

50053

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

3

High-throughput

0.489

High

50059

XPOT
Exportin-T

1

3

High-throughput

0.489

High

50062

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

2

High-throughput

0.489

High

50066

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

2

High-throughput

0.489

High

50068

RHBT3
Rho-related BTB domain-containing protein 3

1

1

High-throughput

0.489

High

50097

MK04
Mitogen-activated protein kinase 4

1

4

High-throughput

0.489

High

50098

CNR2
Cannabinoid receptor 2

1

1

Small-scale

0.489

High

50102

VGFR3
Vascular endothelial growth factor receptor 3

1

1

High-throughput

0.489

High

50136

TBC8B
TBC1 domain family member 8B

1

2

High-throughput

0.489

High

50170

TTC27
Tetratricopeptide repeat protein 27

1

1

High-throughput

0.489

High

50180

ST32C
Serine/threonine-protein kinase 32C

1

2

High-throughput

0.489

High

50203

YLAT2
Y+L amino acid transporter 2

1

1

High-throughput

0.489

High

50210

EVI5L
EVI5-like protein

1

2

High-throughput

0.489

High

50225

TESK2
Dual specificity testis-specific protein kinase 2

1

1

High-throughput

0.489

High

50232

LST8
Target of rapamycin complex subunit LST8

1

1

High-throughput

0.489

High

50233

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.489

High

50250

XPO5
Exportin-5

1

3

High-throughput

0.489

High

50263

C5AR2
C5a anaphylatoxin chemotactic receptor 2

1

1

High-throughput

0.489

High

50269

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

2

High-throughput

0.489

High

50276

TNPO3
Transportin-3

1

2

High-throughput

0.489

High

50083

UBL4A
Ubiquitin-like protein 4A

1

5

High-throughput

0.479

High

50126

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

50151

OASL
2'-5'-oligoadenylate synthase-like protein

1

5

High-throughput

0.479

High

50199

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

50240

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.479

High

50079

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

50082

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

50101

BASI
Basigin

1

0

High-throughput

0.458

High

50103

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

50124

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.458

High

50127

H4
Histone H4

1

0

High-throughput

0.458

High

50139

CLN3
Battenin

1

0

High-throughput

0.458

High

50172

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

50191

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.458

High

50231

DERL1
Derlin-1

1

0

High-throughput

0.458

High

50264

NCDN
Neurochondrin

1

0

High-throughput

0.458

High

50154

NTRK3
NT-3 growth factor receptor

1

2

High-throughput

0.457

High

50048

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.445

High

50063

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

50069

RTN3
Reticulon-3

1

2

High-throughput

0.445

High

50071

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.445

High

50081

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

50085

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

50094

CALR
Calreticulin

1

1

High-throughput

0.445

High

50095

CALX
Calnexin

1

1

High-throughput

0.445

High

50106

PI4KA
Phosphatidylinositol 4-kinase alpha

1

1

High-throughput

0.445

High

50113

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.445

High

50128

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

4

High-throughput

0.445

High

50149

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

50150

DHC24
Delta(24)-sterol reductase

1

2

High-throughput

0.445

High

50161

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.445

High

50195

ATLA2
Atlastin-2

1

2

High-throughput

0.445

High

50202

ATLA1
Atlastin-1

1

2

High-throughput

0.445

High

50211

ASTRA
Protein Aster-A

1

2

High-throughput

0.445

High

50220

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.445

High

50228

ERP44
Endoplasmic reticulum resident protein 44

1

1

High-throughput

0.445

High

50229

ESYT1
Extended synaptotagmin-1

1

2

High-throughput

0.445

High

50243

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.445

High

50253

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

50262

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.445

High

50272

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.445

High

50273

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

50278

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

50248

ECT2
Protein ECT2

1

1

High-throughput

0.439

High

50070

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

50088

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

50090

VGFR1
Vascular endothelial growth factor receptor 1

1

1

High-throughput

0.437

High

50093

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

50096

UFO
Tyrosine-protein kinase receptor UFO

1

2

High-throughput

0.437

High

50099

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

50104

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

50155

MK06
Mitogen-activated protein kinase 6

1

5

High-throughput

0.437

High

50159

Q4LE69
1-phosphatidylinositol 4-kinase

1

1

High-throughput

0.437

High

50174

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

50185

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

50217

AURKB
Aurora kinase B

1

1

High-throughput

0.437

High

50219

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

1

1

High-throughput

0.437

High

50245

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

50267

UBQL2
Ubiquilin-2

1

1

High-throughput

0.437

High

50275

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

50047

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

50057

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.426

High

50064

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

50073

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

50080

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.426

High

50087

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.426

High

50109

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

50110

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.426

High

50115

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.426

High

50118

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

50125

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.426

High

50144

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

50145

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

50146

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

50147

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

50152

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

50171

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

50188

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

50189

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.426

High

50192

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

50193

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

50196

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.426

High

50201

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.426

High

50207

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.426

High

50230

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

50235

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

50237

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.426

High

50241

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

50252

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.426

High

50255

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

50261

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

50270

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

50065

STAM2
Signal transducing adapter molecule 2

1

1

High-throughput

0.407

High

50112

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

3

High-throughput

0.407

High

50132

ARF5
ADP-ribosylation factor 5

1

1

High-throughput

0.407

High

50186

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.407

High

50190

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.407

High

50089

DPEP1
Dipeptidase 1

2

0

High-throughput

0.328

High

50131

COG7
Conserved oligomeric Golgi complex subunit 7

2

0

High-throughput

0.328

High

50165

ZMYM4
Zinc finger MYM-type protein 4

2

0

High-throughput

0.328

High

50173

THADA
tRNA

2

0

High-throughput

0.328

High

50205

PGTA
Geranylgeranyl transferase type-2 subunit alpha

2

0

High-throughput

0.328

High

50209

INT12
Integrator complex subunit 12

2

0

High-throughput

0.328

High

50223

XPO6
Exportin-6

2

0

High-throughput

0.328

High

50254

PICK1
PRKCA-binding protein

2

0

High-throughput

0.328

High

50198

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.299

High

50121

ATX1
Ataxin-1

1

0

High-throughput

0.282

High

50075

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.279

Low

50116

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.279

Low

50142

URB2
Unhealthy ribosome biogenesis protein 2 homolog

1

0

High-throughput

0.279

Low

50156

AMHR2
Anti-Muellerian hormone type-2 receptor

1

0

High-throughput

0.279

Low

50163

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

0

High-throughput

0.279

Low

50177

SV2A
Synaptic vesicle glycoprotein 2A

1

0

High-throughput

0.279

Low

50182

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.279

Low

50184

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

50200

FBLI1
Filamin-binding LIM protein 1

1

0

High-throughput

0.279

Low

50208

SKA1
Spindle and kinetochore-associated protein 1

1

0

High-throughput

0.279

Low

50214

HOOK2
Protein Hook homolog 2

1

0

High-throughput

0.279

Low

50215

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

50218

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.279

Low

50249

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.279

Low

50257

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.279

Low

50271

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.279

Low

50274

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.279

Low

50135

COEA1
Collagen alpha-1(XIV) chain

1

0

High-throughput

0.269

Low

50092

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.261

Low

50052

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

50054

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.249

Low

50058

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

50072

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

50091

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.249

Low

50111

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

50129

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

50134

FAK1
Focal adhesion kinase 1

1

0

High-throughput

0.249

Low

50157

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

50158

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

50167

FTM
Protein fantom

1

0

High-throughput

0.249

Low

50168

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

50169

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

50175

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

50178

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

50181

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

50206

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

50212

FAF2
FAS-associated factor 2

1

0

High-throughput

0.249

Low

50213

OPTN
Optineurin

1

0

High-throughput

0.249

Low

50221

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

50266

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

50056

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.232

Low

50067

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.232

Low

50114

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.232

Low

50130

NUCB2
Nucleobindin-2

1

0

High-throughput

0.232

Low

50133

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.232

Low

50138

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.232

Low

50148

RCN1
Reticulocalbin-1

1

0

High-throughput

0.232

Low

50160

ZNG1F
Zinc-regulated GTPase metalloprotein activator 1F

1

0

High-throughput

0.232

Low

50176

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.232

Low

50194

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.232

Low

50222

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.232

Low

50224

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

50227

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

50239

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.232

Low

50258

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

50259

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

50260

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.232

Low

50277

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024