Protein: SMG5
Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5)

Gene: SMG5
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q9UPR3

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0005634 - nucleus
GO:0005697 - telomerase holoenzyme complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1364016

SMG7
Nonsense-mediated mRNA decay factor SMG7

3

4

Small-scale

0.834

High

1288992

EST1A
Telomerase-binding protein EST1A

2

4

Small-scale

0.754

High

414860

P53
Cellular tumor antigen p53

3

1

Small-scale

0.662

High

1370168

RENT1
Regulator of nonsense transcripts 1

3

6

Small-scale

0.657

High

346508

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

1211466

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.574

High

162981

TERT
Telomerase reverse transcriptase

1

1

Small-scale

0.561

High

1462269

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.561

High

1417908

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

1123552

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

946909

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.515

High

1163292

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.515

High

1408068

H2B1L
Histone H2B type 1-L

1

2

High-throughput

0.515

High

1178916

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.489

High

1331881

SYT2
Synaptotagmin-2

1

1

High-throughput

0.489

High

423467

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

48107

RBM47
RNA-binding protein 47

1

4

High-throughput

0.479

High

176577

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.479

High

274265

ANR17
Ankyrin repeat domain-containing protein 17

1

3

High-throughput

0.479

High

324238

CE152
Centrosomal protein of 152 kDa

1

1

High-throughput

0.479

High

688342

TTP
mRNA decay activator protein ZFP36

1

3

High-throughput

0.479

High

713873

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

3

High-throughput

0.479

High

766945

PHB1
Prohibitin 1

1

1

Small-scale

0.479

High

875836

PRC2A
Protein PRRC2A

1

7

High-throughput

0.479

High

900227

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.479

High

1032442

OTUD4
OTU domain-containing protein 4

1

3

High-throughput

0.479

High

1091476

ANK3
Ankyrin-3

1

2

High-throughput

0.479

High

1122199

UBP2L
Ubiquitin-associated protein 2-like

1

4

High-throughput

0.479

High

1129539

PUM1
Pumilio homolog 1

1

1

High-throughput

0.479

High

1143594

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.479

High

1165529

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

5

High-throughput

0.479

High

1208604

SMAG2
Protein Smaug homolog 2

1

1

High-throughput

0.479

High

1241611

CEP85
Centrosomal protein of 85 kDa

1

1

High-throughput

0.479

High

1252420

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

1256114

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1280775

YTHD3
YTH domain-containing family protein 3

1

6

High-throughput

0.479

High

1287157

PATL1
Protein PAT1 homolog 1

1

4

High-throughput

0.479

High

1310679

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

1

High-throughput

0.479

High

1316486

XRN1
5'-3' exoribonuclease 1

1

3

High-throughput

0.479

High

1336332

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.479

High

1336889

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

5

High-throughput

0.479

High

1356342

SMAP2
Stromal membrane-associated protein 2

1

1

High-throughput

0.479

High

1365395

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.479

High

1369876

CELF1
CUGBP Elav-like family member 1

1

3

High-throughput

0.479

High

1370261

DAZL
Deleted in azoospermia-like

1

5

High-throughput

0.479

High

1393981

FUBP3
Far upstream element-binding protein 3

1

3

High-throughput

0.479

High

1397053

CNO6L
CCR4-NOT transcription complex subunit 6-like

1

1

High-throughput

0.479

High

1411378

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.479

High

1417729

HDAC8
Histone deacetylase 8

1

2

Small-scale

0.479

High

1419555

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

3

High-throughput

0.479

High

1420683

UNK
RING finger protein unkempt homolog

1

4

High-throughput

0.479

High

1429253

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

2

High-throughput

0.479

High

1434246

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1435462

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1435709

TDRD3
Tudor domain-containing protein 3

1

2

High-throughput

0.479

High

1438900

MOV10
Helicase MOV-10

1

6

High-throughput

0.479

High

1446494

DCP1A
mRNA-decapping enzyme 1A

1

1

High-throughput

0.479

High

1448124

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.479

High

1451644

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

2

High-throughput

0.479

High

1453513

CNOT2
CCR4-NOT transcription complex subunit 2

1

3

High-throughput

0.479

High

1460494

CNOT7
CCR4-NOT transcription complex subunit 7

1

1

High-throughput

0.479

High

1462536

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

4

High-throughput

0.479

High

1462552

FBW1A
F-box/WD repeat-containing protein 1A

1

2

High-throughput

0.479

High

1462553

R3HD2
R3H domain-containing protein 2

1

5

High-throughput

0.479

High

1462555

YTHD2
YTH domain-containing family protein 2

1

6

High-throughput

0.479

High

1462556

RBM8A
RNA-binding protein 8A

1

4

Small-scale

0.479

High

1462557

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

5

High-throughput

0.479

High

329998

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

Small-scale

0.458

High

1459888

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

1419960

REN3B
Regulator of nonsense transcripts 3B

1

2

Small-scale

0.445

High

1431131

REN3A
Regulator of nonsense transcripts 3A

1

2

Small-scale

0.445

High

1448565

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1219913

OBI1
ORC ubiquitin ligase 1

1

1

High-throughput

0.437

High

1336231

RN214
RING finger protein 214

1

1

High-throughput

0.437

High

1433474

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.437

High

1462554

RT18C
Small ribosomal subunit protein bS18m

2

0

High-throughput

0.313

High


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Last updated: 11Aug2025