HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: PPP5 (P53041)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Gene: PPP5C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15383005
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 840 Hs			1 499
+	Hs
		714115 HSP74_HUMAN (1-840): 0: 993: 100.00		PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88
+	Hs
		714169 HSP74_HUMAN (1-840): 0: 993: 100.00		PP1B_HUMAN (203-490): 1.32e-154: 444: 36.09
+	Hs
		714168 HSP74_HUMAN (1-840): 0: 993: 100.00		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Hs
		156620 HS105_HUMAN (1-840): 0: 938: 62.95		PPE1_HUMAN (156-487): 8.16e-68: 231: 34.12
+	Sc
		618758 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		PP2A1_YEAST (162-488): 6.84e-165: 472: 35.67
+	Sc
		618822 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		PP2A2_YEAST (164-482): 4.86e-162: 465: 35.00
+	Sc
		695109 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		PPT1_YEAST (20-492): 1.85e-158: 461: 37.95
+	Sc
		694336 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		PP12_YEAST (196-479): 9.87e-151: 434: 39.65
+	Hs
		503738 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		PPP5_HUMAN (1-499): 0: 575: 100.00
+	Mm
		926131 HSP7C_MOUSE (564-692): 1.76e-19: 95.5: 16.15		PPP5_MOUSE (1-499): 0: 571: 97.80
+	Hs
		503863 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88
+	Hs
		503837 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69
+	Hs
		503566 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88
+	Hs
		503821 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Hs
		713915 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88
+	Hs
		905943 Q53FA3_HUMAN (564-691): 3.83e-19: 94.3: 23.26		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Hs
		713936 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79
+	Mm
		571849 HS71B_MOUSE (571-686): 9.97e-18: 89.7: 23.08		PP1A_MOUSE (200-479): 2.47e-154: 444: 38.79
+	Mm
		571850 HS71B_MOUSE (571-686): 9.97e-18: 89.7: 23.08		PP1B_MOUSE (203-490): 1.32e-154: 444: 36.09
+	Hs
		156595 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		PPE1_HUMAN (156-487): 8.16e-68: 231: 34.12