Protein: KDM3B
Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B)

Gene: KDM3B
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q7LBC6

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000785 - chromatin
GO:0003712 - transcription coregulator activity
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1257242

RFPLB
Ret finger protein-like 4B

3

6

High-throughput

0.667

High

1273153

TRI11
E3 ubiquitin-protein ligase TRIM11

2

3

High-throughput

0.628

High

1273141

KDM3B
Lysine-specific demethylase 3B

1

11

High-throughput

0.618

High

1273162

RNF41
E3 ubiquitin-protein ligase NRDP1

2

6

Small-scale

0.606

High

488238

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.602

High

581419

CBPN
Carboxypeptidase N catalytic chain

2

0

High-throughput

0.602

High

1273164

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

0

High-throughput

0.585

High

242112

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

260118

BRD4
Bromodomain-containing protein 4

2

5

High-throughput

0.584

High

372405

MYC
Myc proto-oncogene protein

2

7

High-throughput

0.584

High

520161

ANDR
Androgen receptor

2

20

High-throughput

0.584

High

424516

PAI2
Plasminogen activator inhibitor 2

2

2

High-throughput

0.574

High

1273152

RM38
Large ribosomal subunit protein mL38

2

1

High-throughput

0.574

High

271271

CPNE3
Copine-3

1

1

High-throughput

0.536

High

370321

CYTA
Cystatin-A

1

1

High-throughput

0.536

High

407645

S100B
Protein S100-B

1

2

High-throughput

0.536

High

1014139

CBX1
Chromobox protein homolog 1

1

8

High-throughput

0.536

High

1099714

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

1153973

SMAD1
Mothers against decapentaplegic homolog 1

1

5

High-throughput

0.536

High

1273159

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

1273166

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.536

High

274641

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

926197

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.513

High

1030466

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.513

High

1273144

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1273149

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

1273154

Z512B
Zinc finger protein 512B

1

4

High-throughput

0.508

High

1273156

SPAG8
Sperm-associated antigen 8

1

1

High-throughput

0.508

High

508194

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

1161916

H31T
Histone H3.1t

1

14

Small-scale

0.501

High

347133

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

365764

KAD1
Adenylate kinase isoenzyme 1

1

1

High-throughput

0.489

High

706185

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

772874

MYH9
Myosin-9

1

3

High-throughput

0.489

High

966528

1433G
14-3-3 protein gamma

1

19

High-throughput

0.489

High

1042023

LMNB2
Lamin-B2

1

5

High-throughput

0.489

High

1049481

1433F
14-3-3 protein eta

1

19

High-throughput

0.489

High

1215441

DEP1A
DEP domain-containing protein 1A

1

1

High-throughput

0.489

High

1273160

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.489

High

1273171

UBP18
Ubl carboxyl-terminal hydrolase 18

1

6

High-throughput

0.489

High

1273150

CBP
CREB-binding protein

1

11

Small-scale

0.481

High

129211

MEN1
Menin

1

4

High-throughput

0.479

High

172995

XPO1
Exportin-1

1

10

High-throughput

0.479

High

404158

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

537407

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

589015

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

606875

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

695802

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

714221

PML
Protein PML

1

9

High-throughput

0.479

High

768513

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

862252

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

879222

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

886987

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.479

High

934789

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

998477

H31
Histone H3.1

1

14

High-throughput

0.479

High

1016979

H33
Histone H3.3

1

14

High-throughput

0.479

High

1113517

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1146240

ZMY11
Zinc finger MYND domain-containing protein 11

1

6

Small-scale

0.479

High

1217734

GFI1B
Zinc finger protein Gfi-1b

1

1

Small-scale

0.479

High

1254390

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1273142

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1273143

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1273145

SLX4
Structure-specific endonuclease subunit SLX4

1

13

High-throughput

0.479

High

1273147

TOPB1
DNA topoisomerase 2-binding protein 1

1

8

High-throughput

0.479

High

1273148

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1273151

OPTN
Optineurin

1

10

High-throughput

0.479

High

1273157

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.479

High

1273163

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1273167

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

1273169

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1273170

NUP50
Nuclear pore complex protein Nup50

1

4

High-throughput

0.479

High

1177583

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.458

High

408960

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.437

High

412160

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

995663

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.437

High

1273146

ARL10
ADP-ribosylation factor-like protein 10

1

1

High-throughput

0.437

High

1273161

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.437

High

1273168

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.437

High

530013

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.407

High

450311

TY3H
Tyrosine 3-monooxygenase

2

0

High-throughput

0.328

High

1038892

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

0

High-throughput

0.328

High

683737

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.279

Low

692730

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

893623

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1273155

O52B2
Olfactory receptor 52B2

1

0

High-throughput

0.279

Low

1273158

TOLIP
Toll-interacting protein

1

0

High-throughput

0.279

Low

1258335

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

1273165

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025