HitPredict

Interactor 1: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Interactor 2: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10642522
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0006457 - protein folding GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 840 Hs			1 459
+	Hs
		714212 HSP74_HUMAN (1-840): 0: 993: 100.00		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		684440 HSP74_HUMAN (1-840): 0: 993: 100.00		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		320819 HS74L_HUMAN (1-840): 0: 959: 63.21		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		684925 HS105_HUMAN (1-840): 0: 938: 62.95		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Dm
		1359201 Q9VUC1_DROME (1-840): 0: 821: 42.10		Q9V3V2_DROME (50-134): 1.49e-18: 85.9: 52.33
+	Hs
		503930 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00
+	Sc
		589271 HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61		FKBP_YEAST (147-253): 1.31e-22: 94.1: 23.01
+	Hs
		504028 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		713959 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		503968 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		PPID_HUMAN (251-416): 8.47e-51: 177: 28.14
+	Hs
		504875 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		AIPL1_HUMAN (141-421): 2.12e-50: 177: 18.34
+	Hs
		713971 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		FKBP8_HUMAN (26-337): 2.99e-32: 128: 18.30
+	Hs
		504536 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		FKB10_HUMAN (24-136): 4.21e-24: 107: 33.33
+	At
		1338008 HS704_ARATH (486-691): 1.05e-17: 89.7: 15.57		HSOP1_ARATH (189-452): 4.33e-19: 91.8: 15.85
+	Hs
		503534 HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		483776 HS71B_HUMAN (571-686): 1.59e-19: 95.5: 23.93		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		684439 HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		564017 HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51