Protein: TRI66
Tripartite motif-containing protein 66

Gene: TRI66, TRIM66
Organism: Homo sapiens
Interactions: 200
UniProt ID: O15016

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

174487

PML
Protein PML

1

18

High-throughput

0.618

High

174529

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.618

High

174534

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

20

High-throughput

0.618

High

174572

PHIP
PH-interacting protein

1

20

High-throughput

0.618

High

174601

AFG2B
ATPase family gene 2 protein homolog B

1

9

High-throughput

0.618

High

174633

BAZ1B
Tyrosine-protein kinase BAZ1B

1

19

High-throughput

0.618

High

174642

PHF8
Histone lysine demethylase PHF8

1

6

High-throughput

0.618

High

174465

PEX1
Peroxisomal ATPase PEX1

1

9

High-throughput

0.553

High

174525

ATD3B
ATPase family AAA domain-containing protein 3B

1

20

High-throughput

0.553

High

174561

AFG2A
ATPase family gene 2 protein homolog A

1

9

High-throughput

0.553

High

174505

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

14

High-throughput

0.541

High

136232

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.479

High

174282

ZN609
Zinc finger protein 609

1

11

High-throughput

0.479

High

174459

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

12

High-throughput

0.479

High

174460

P73
Tumor protein p73

1

18

High-throughput

0.479

High

174463

WDR62
WD repeat-containing protein 62

1

17

High-throughput

0.479

High

174464

AKAP8
A-kinase anchor protein 8

1

8

High-throughput

0.479

High

174466

GANP
Germinal-center associated nuclear protein

1

5

High-throughput

0.479

High

174469

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.479

High

174473

ZIC2
Zinc finger protein ZIC 2

1

20

High-throughput

0.479

High

174476

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.479

High

174477

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

10

High-throughput

0.479

High

174478

P53
Cellular tumor antigen p53

1

18

High-throughput

0.479

High

174479

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.479

High

174482

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

High-throughput

0.479

High

174483

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

4

High-throughput

0.479

High

174484

JAK1
Tyrosine-protein kinase JAK1

1

20

High-throughput

0.479

High

174485

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

High-throughput

0.479

High

174488

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

High-throughput

0.479

High

174489

WEE1
Wee1-like protein kinase

1

16

High-throughput

0.479

High

174492

AHR
Aryl hydrocarbon receptor

1

15

High-throughput

0.479

High

174494

MLH1
DNA mismatch repair protein Mlh1

1

5

High-throughput

0.479

High

174495

MRE11
Double-strand break repair protein MRE11

1

2

High-throughput

0.479

High

174496

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

6

High-throughput

0.479

High

174498

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

20

High-throughput

0.479

High

174503

NOTC2
Neurogenic locus notch homolog protein 2

1

13

High-throughput

0.479

High

174511

FAT1
Protocadherin Fat 1

1

2

High-throughput

0.479

High

174514

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

11

High-throughput

0.479

High

174515

SKI2
Superkiller complex protein 2

1

20

High-throughput

0.479

High

174516

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

5

High-throughput

0.479

High

174517

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

17

High-throughput

0.479

High

174522

PCID2
PCI domain-containing protein 2

1

7

High-throughput

0.479

High

174533

SKI3
Superkiller complex protein 3

1

14

High-throughput

0.479

High

174535

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

174536

SAMD1
Sterile alpha motif domain-containing protein 1

1

15

High-throughput

0.479

High

174538

BCOR
BCL-6 corepressor

1

15

High-throughput

0.479

High

174546

SLN11
Schlafen family member 11

1

3

High-throughput

0.479

High

174548

CUL9
Cullin-9

1

12

High-throughput

0.479

High

174552

WDFY3
WD repeat and FYVE domain-containing protein 3

1

8

High-throughput

0.479

High

174553

ASPM
Abnormal spindle-like microcephaly-associated protein

1

16

High-throughput

0.479

High

174558

EFNMT
eEF1A lysine and N-terminal methyltransferase

1

3

High-throughput

0.479

High

174559

TRIML
Probable E3 ubiquitin-protein ligase TRIML1

1

19

High-throughput

0.479

High

174560

MLKL
Mixed lineage kinase domain-like protein

1

7

High-throughput

0.479

High

174570

PHLA1
Pleckstrin homology-like domain family A member 1

1

6

High-throughput

0.479

High

174574

ELYS
Protein ELYS

1

12

High-throughput

0.479

High

174576

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

174578

PROX1
Prospero homeobox protein 1

1

1

High-throughput

0.479

High

174581

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

5

High-throughput

0.479

High

174585

PDLI2
PDZ and LIM domain protein 2

1

5

High-throughput

0.479

High

174589

PASK
PAS domain-containing serine/threonine-protein kinase

1

9

High-throughput

0.479

High

174594

PKP4
Plakophilin-4

1

15

High-throughput

0.479

High

174596

PKP2
Plakophilin-2

1

20

High-throughput

0.479

High

174600

GNL3
Guanine nucleotide-binding protein-like 3

1

7

High-throughput

0.479

High

174604

FACD2
Fanconi anemia group D2 protein

1

8

High-throughput

0.479

High

174605

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

20

High-throughput

0.479

High

174607

SETD2
Histone-lysine N-methyltransferase SETD2

1

15

High-throughput

0.479

High

174609

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

14

High-throughput

0.479

High

174611

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

10

High-throughput

0.479

High

174612

ZN768
Zinc finger protein 768

1

20

High-throughput

0.479

High

174619

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

High-throughput

0.479

High

174620

RNC
Ribonuclease 3

1

5

High-throughput

0.479

High

174624

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

3

High-throughput

0.479

High

174625

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

3

High-throughput

0.479

High

174626

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

20

High-throughput

0.479

High

174627

SENP1
Sentrin-specific protease 1

1

6

High-throughput

0.479

High

174630

ZN629
Zinc finger protein 629

1

20

High-throughput

0.479

High

174631

MLH3
DNA mismatch repair protein Mlh3

1

5

High-throughput

0.479

High

174634

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

174636

AGO2
Protein argonaute-2

1

12

High-throughput

0.479

High

174637

MTUS1
Microtubule-associated tumor suppressor 1

1

20

High-throughput

0.479

High

174638

ZN608
Zinc finger protein 608

1

9

High-throughput

0.479

High

174639

AKP8L
A-kinase anchor protein 8-like

1

8

High-throughput

0.479

High

174641

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

3

High-throughput

0.479

High

174644

PDIP2
Polymerase delta-interacting protein 2

1

1

High-throughput

0.479

High

174645

ZN281
Zinc finger protein 281

1

20

High-throughput

0.479

High

174497

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.458

High

174527

ZN318
Zinc finger protein 318

1

0

High-throughput

0.458

High

174545

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

174593

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

174595

METH
Methionine synthase

1

0

High-throughput

0.458

High

174621

PANK4
4'-phosphopantetheine phosphatase

1

0

High-throughput

0.458

High

174635

FBX5
F-box only protein 5

1

0

High-throughput

0.458

High

174646

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

174648

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.458

High

50442

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.437

High

76078

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

14

High-throughput

0.437

High

163206

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

4

High-throughput

0.437

High

174456

SC16A
Protein transport protein Sec16A

1

4

High-throughput

0.437

High

174457

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.437

High

174458

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

6

High-throughput

0.437

High

174461

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

5

High-throughput

0.437

High

174462

ADCY6
Adenylate cyclase type 6

1

1

High-throughput

0.437

High

174467

GGYF1
GRB10-interacting GYF protein 1

1

8

High-throughput

0.437

High

174468

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

19

High-throughput

0.437

High

174471

RHBT3
Rho-related BTB domain-containing protein 3

1

9

High-throughput

0.437

High

174472

MTCL2
Microtubule cross-linking factor 2

1

20

High-throughput

0.437

High

174474

AGRL2
Adhesion G protein-coupled receptor L2

1

1

High-throughput

0.437

High

174475

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.437

High

174480

BCR
Breakpoint cluster region protein

1

9

High-throughput

0.437

High

174486

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

11

High-throughput

0.437

High

174490

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

10

High-throughput

0.437

High

174491

ATP7B
Copper-transporting ATPase 2

1

3

High-throughput

0.437

High

174493

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.437

High

174500

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.437

High

174501

VLDLR
Very low-density lipoprotein receptor

1

4

High-throughput

0.437

High

174502

AT2C1
Calcium-transporting ATPase type 2C member 1

1

4

High-throughput

0.437

High

174504

LG3BP
Galectin-3-binding protein

1

10

High-throughput

0.437

High

174506

DSG2
Desmoglein-2

1

7

High-throughput

0.437

High

174507

MAP7
Ensconsin

1

20

High-throughput

0.437

High

174508

FLOT2
Flotillin-2

1

3

High-throughput

0.437

High

174509

RCN2
Reticulocalbin-2

1

8

High-throughput

0.437

High

174510

GAS6
Growth arrest-specific protein 6

1

16

High-throughput

0.437

High

174513

CUL7
Cullin-7

1

7

High-throughput

0.437

High

174518

KIF7
Kinesin-like protein KIF7

1

14

High-throughput

0.437

High

174519

MA7D1
MAP7 domain-containing protein 1

1

19

High-throughput

0.437

High

174520

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.437

High

174521

PRC2B
Protein PRRC2B

1

20

High-throughput

0.437

High

174523

NU188
Nucleoporin NUP188

1

1

High-throughput

0.437

High

174524

CE170
Centrosomal protein of 170 kDa

1

18

High-throughput

0.437

High

174528

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

2

High-throughput

0.437

High

174531

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

4

High-throughput

0.437

High

174532

TTC27
Tetratricopeptide repeat protein 27

1

10

High-throughput

0.437

High

174537

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

3

High-throughput

0.437

High

174540

FA83H
Protein FAM83H

1

1

High-throughput

0.437

High

174541

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

1

High-throughput

0.437

High

174542

SV2A
Synaptic vesicle glycoprotein 2A

1

1

High-throughput

0.437

High

174543

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.437

High

174544

MON2
Protein MON2 homolog

1

4

High-throughput

0.437

High

174547

ZDH13
Palmitoyltransferase ZDHHC13

1

10

High-throughput

0.437

High

174549

DJC10
DnaJ homolog subfamily C member 10

1

16

High-throughput

0.437

High

174550

MIRO1
Mitochondrial Rho GTPase 1

1

6

High-throughput

0.437

High

174555

RPTOR
Regulatory-associated protein of mTOR

1

15

High-throughput

0.437

High

174556

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

2

High-throughput

0.437

High

174557

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

10

High-throughput

0.437

High

174562

ARRD4
Arrestin domain-containing protein 4

1

8

High-throughput

0.437

High

174563

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

19

High-throughput

0.437

High

174564

COQ8A
Atypical kinase COQ8A, mitochondrial

1

2

High-throughput

0.437

High

174565

PCD19
Protocadherin-19

1

2

High-throughput

0.437

High

174567

CERK1
Ceramide kinase

1

1

High-throughput

0.437

High

174568

ALMS1
Centrosome-associated protein ALMS1

1

9

High-throughput

0.437

High

174569

FAT3
Protocadherin Fat 3

1

3

High-throughput

0.437

High

174573

ASB11
Ankyrin repeat and SOCS box protein 11

1

10

High-throughput

0.437

High

174575

DNS2B
Deoxyribonuclease-2-beta

1

3

High-throughput

0.437

High

174577

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

High-throughput

0.437

High

174579

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

174580

GCP3
Gamma-tubulin complex component 3

1

4

High-throughput

0.437

High

174582

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

10

High-throughput

0.437

High

174584

TMX3
Protein disulfide-isomerase TMX3

1

15

High-throughput

0.437

High

174586

MARK4
MAP/microtubule affinity-regulating kinase 4

1

7

High-throughput

0.437

High

174587

SFXN2
Sideroflexin-2

1

1

High-throughput

0.437

High

174588

CSMD1
CUB and sushi domain-containing protein 1

1

9

High-throughput

0.437

High

174590

GCP6
Gamma-tubulin complex component 6

1

4

High-throughput

0.437

High

174591

GCP5
Gamma-tubulin complex component 5

1

4

High-throughput

0.437

High

174592

IF140
Intraflagellar transport protein 140 homolog

1

7

High-throughput

0.437

High

174597

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.437

High

174598

PELO
Protein pelota homolog

1

2

High-throughput

0.437

High

174599

GCP2
Gamma-tubulin complex component 2

1

4

High-throughput

0.437

High

174602

GTPB2
GTP-binding protein 2

1

10

High-throughput

0.437

High

174603

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.437

High

174608

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

High-throughput

0.437

High

174613

YTDC2
3'-5' RNA helicase YTHDC2

1

20

High-throughput

0.437

High

174614

NT5D2
5'-nucleotidase domain-containing protein 2

1

1

High-throughput

0.437

High

174617

WDR6
tRNA

1

20

High-throughput

0.437

High

174618

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

11

High-throughput

0.437

High

174622

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

7

High-throughput

0.437

High

174623

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.437

High

174628

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

4

High-throughput

0.437

High

174629

CRNN
Cornulin

1

19

High-throughput

0.437

High

174632

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

2

High-throughput

0.437

High

174640

DIM1
Dimethyladenosine transferase

1

1

High-throughput

0.437

High

174643

SIK3
Serine/threonine-protein kinase SIK3

1

5

High-throughput

0.437

High

174647

IRS2
Insulin receptor substrate 2

1

15

High-throughput

0.437

High

67097

CP096
Uncharacterized protein C16orf96

1

0

High-throughput

0.249

Low

162070

ACOT8
Acyl-coenzyme A thioesterase 8

1

0

High-throughput

0.249

Low

174470

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.249

Low

174481

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.249

Low

174499

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.249

Low

174512

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.249

Low

174526

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.249

Low

174530

CRBG3
Very large A-kinase anchor protein

1

0

High-throughput

0.249

Low

174539

THADA
tRNA

1

0

High-throughput

0.249

Low

174551

TRM2A
tRNA

1

0

High-throughput

0.249

Low

174554

FCSK
L-fucose kinase

1

0

High-throughput

0.249

Low

174566

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.249

Low

174571

FACR1
Fatty acyl-CoA reductase 1

1

0

High-throughput

0.249

Low

174583

VPS50
Syndetin

1

0

High-throughput

0.249

Low

174606

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.249

Low

174610

CE295
Centrosomal protein of 295 kDa

1

0

High-throughput

0.249

Low

174615

VEZA
Vezatin

1

0

High-throughput

0.249

Low

174616

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025