HitPredict

Interactor 1: CRFR1 (P34998)
Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
Gene: CRHR1

Interactor 2: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	23576434, 30126976
Identification Methods	pull down, affinity chromatography technology, p8 filamentous phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043005 - neuron projection
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 415 Hs			1 904
+	Hs
		146753 AGRB1_HUMAN (3-377): 4.14e-79: 268: 19.69		DLG1_HUMAN (1-904): 0: 725: 100.00
+	Mm
		722926 CRFR1_MOUSE (1-415): 1.03e-129: 381: 97.59		DLG3_MOUSE (99-904): 0: 589: 64.69
+	Mm
		722927 CRFR1_MOUSE (1-415): 1.03e-129: 381: 97.59		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Hs
		714731 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64
+	Hs
		714734 CRFR1_HUMAN (1-415): 8.88e-129: 379: 100.00		SCRIB_HUMAN (217-396): 1.59e-23: 109: 41.49
+	Mm
		1143372 AGRL3_MOUSE (1-413): 4.15e-117: 375: 19.18		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Mm
		1143371 AGRL1_MOUSE (6-413): 6.78e-113: 362: 18.20		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Mm
		1143383 AGRB3_MOUSE (4-392): 9.99e-81: 272: 19.48		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Mm
		1112552 AGRB1_MOUSE (3-377): 2.02e-80: 271: 19.95		DLG4_MOUSE (86-477): 2.03e-24: 111: 16.07
+	Hs
		146752 AGRB1_HUMAN (3-377): 4.14e-79: 268: 19.69		DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64