Protein: SPA12
Serpin A12 (OL-64) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (Visceral adipose-specific serpin)

Gene: SPA12, SERPINA12
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q8IW75

Gene Ontology (top 5):
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0006094 - gluconeogenesis
GO:0008610 - lipid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

274894

LRP5
Low-density lipoprotein receptor-related protein 5

2

1

High-throughput

0.811

High

1309607

NECT2
Nectin-2

2

2

High-throughput

0.811

High

659039

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

3

0

High-throughput

0.811

High

1309633

TM11E
Transmembrane protease serine 11E

1

18

High-throughput

0.691

High

1133829

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

6

High-throughput

0.667

High

462897

LAMB1
Laminin subunit beta-1

3

2

High-throughput

0.662

High

222381

TSN6
Tetraspanin-6

2

5

High-throughput

0.628

High

584564

VAV
Proto-oncogene vav

2

1

High-throughput

0.628

High

603796

ITA2
Integrin alpha-2

2

5

High-throughput

0.628

High

1112586

CUL1
Cullin-1

2

5

High-throughput

0.628

High

1249734

SE6L2
Seizure 6-like protein 2

2

1

High-throughput

0.628

High

1309621

K1549
UPF0606 protein KIAA1549

2

1

High-throughput

0.628

High

943852

CF298
Cilia- and flagella-associated protein 298

3

4

High-throughput

0.609

High

1295661

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

3

1

High-throughput

0.609

High

1309610

GMCL1
Germ cell-less protein-like 1

3

1

High-throughput

0.609

High

1309616

SC22C
Vesicle-trafficking protein SEC22c

3

1

High-throughput

0.609

High

1309625

PLK2
Serine/threonine-protein kinase PLK2

3

3

High-throughput

0.609

High

1206084

TGO1
Transport and Golgi organization protein 1 homolog

3

9

High-throughput

0.604

High

1309589

WDR75
WD repeat-containing protein 75

3

4

High-throughput

0.604

High

1309611

TXD15
Thioredoxin domain-containing protein 15

3

3

High-throughput

0.604

High

1309604

AGRV1
Adhesion G-protein coupled receptor V1

2

0

High-throughput

0.602

High

1309627

TEN3
Teneurin-3

2

0

High-throughput

0.602

High

580799

PVR
Poliovirus receptor

1

2

High-throughput

0.575

High

318508

TOX4
TOX high mobility group box family member 4

2

10

High-throughput

0.574

High

391633

FRIH
Ferritin heavy chain

2

4

High-throughput

0.574

High

1144409

NONO
Non-POU domain-containing octamer-binding protein

2

3

High-throughput

0.574

High

1309624

RFOX1
RNA binding protein fox-1 homolog 1

2

1

High-throughput

0.574

High

1309636

FCF1
rRNA-processing protein FCF1 homolog

2

3

High-throughput

0.574

High

292679

RENR
Renin receptor

1

6

High-throughput

0.536

High

420257

IFNA4
Interferon alpha-4

1

2

High-throughput

0.536

High

618397

TSN8
Tetraspanin-8

1

5

High-throughput

0.536

High

722796

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

1

High-throughput

0.536

High

760763

CD68
Macrosialin

1

1

High-throughput

0.536

High

943088

STX17
Syntaxin-17

1

9

High-throughput

0.536

High

1309598

EHBP1
EH domain-binding protein 1

1

1

High-throughput

0.536

High

1309600

MYBPP
MYCBP-associated protein

1

1

High-throughput

0.536

High

1086034

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

1309591

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.513

High

1309599

DIK2A
Divergent protein kinase domain 2A

1

0

High-throughput

0.513

High

213418

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

1

High-throughput

0.504

High

185210

FANCG
Fanconi anemia group G protein

1

2

High-throughput

0.489

High

219817

CHSTA
Carbohydrate sulfotransferase 10

1

4

High-throughput

0.489

High

231242

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

2

High-throughput

0.489

High

252533

SEP15
Selenoprotein F

1

4

High-throughput

0.489

High

639265

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

High-throughput

0.489

High

666864

CCNC
Cyclin-C

1

6

High-throughput

0.489

High

983674

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

4

High-throughput

0.489

High

1040733

ENL
Protein ENL

1

1

High-throughput

0.489

High

1094519

ZN154
Zinc finger protein 154

1

2

High-throughput

0.489

High

1133402

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

1

High-throughput

0.489

High

1197489

VWA3B
von Willebrand factor A domain-containing protein 3B

1

1

High-throughput

0.489

High

1203534

LRC10
Leucine-rich repeat-containing protein 10

1

3

High-throughput

0.489

High

1290376

MOGT3
2-acylglycerol O-acyltransferase 3

1

6

High-throughput

0.489

High

1292316

ZC3C1
Zinc finger C3HC-type protein 1

1

4

High-throughput

0.489

High

1292958

AROS
Active regulator of SIRT1

1

2

High-throughput

0.489

High

1293842

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

2

High-throughput

0.489

High

1307965

EPHX4
Epoxide hydrolase 4

1

3

High-throughput

0.489

High

1309602

TRI41
E3 ubiquitin-protein ligase TRIM41

1

5

High-throughput

0.489

High

1309603

ZDH19
Palmitoyltransferase ZDHHC19

1

3

High-throughput

0.489

High

1309605

THAP4
Peroxynitrite isomerase THAP4

1

3

High-throughput

0.489

High

1309606

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

1

4

High-throughput

0.489

High

1309608

SARAF
Store-operated calcium entry-associated regulatory factor

1

9

High-throughput

0.489

High

1309613

TEFM
Transcription elongation factor, mitochondrial

1

4

High-throughput

0.489

High

1309620

HES4
Transcription factor HES-4

1

6

High-throughput

0.489

High

1309622

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

2

High-throughput

0.489

High

1309623

TSSP
Thymus-specific serine protease

1

5

High-throughput

0.489

High

1309626

DTL
Denticleless protein homolog

1

3

High-throughput

0.489

High

1309629

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

6

High-throughput

0.489

High

1309632

PCOC2
Procollagen C-endopeptidase enhancer 2

1

1

High-throughput

0.489

High

1309634

PHF8
Histone lysine demethylase PHF8

1

3

High-throughput

0.489

High

1309635

FOXJ3
Forkhead box protein J3

1

4

High-throughput

0.489

High

537470

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

1309614

RANB9
Ran-binding protein 9

1

5

Small-scale

0.479

High

1022743

XIAP
E3 ubiquitin-protein ligase XIAP

1

3

High-throughput

0.457

High

261219

NSMA
Sphingomyelin phosphodiesterase 2

1

7

High-throughput

0.445

High

839476

PI4KA
Phosphatidylinositol 4-kinase alpha

1

11

High-throughput

0.445

High

1043637

COAA1

1

5

High-throughput

0.445

High

293975

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

872504

SOX2
Transcription factor SOX-2

1

9

High-throughput

0.437

High

1195662

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

11

High-throughput

0.437

High

1309618

FACD2
Fanconi anemia group D2 protein

1

10

High-throughput

0.437

High

591324

CD44
CD44 antigen

1

0

High-throughput

0.426

High

883056

AMPH
Amphiphysin

1

0

High-throughput

0.426

High

219643

B2L11
Bcl-2-like protein 11

1

2

High-throughput

0.407

High

698854

CALX
Calnexin

1

4

High-throughput

0.407

High

1105503

OS9
Protein OS-9

1

5

High-throughput

0.407

High

1154389

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.407

High

1177020

INF2
Inverted formin-2

1

3

High-throughput

0.407

High

1227012

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.407

High

1309590

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

High-throughput

0.407

High

1309593

S35F6
Solute carrier family 35 member F6

1

1

High-throughput

0.407

High

1309594

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

11

High-throughput

0.407

High

1309612

MIA2
Melanoma inhibitory activity protein 2

1

10

High-throughput

0.407

High

1309615

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.407

High

1309628

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

5

High-throughput

0.407

High

1309630

TCAL9
Transcription elongation factor A protein-like 9

1

2

High-throughput

0.407

High

1309631

FBX2
F-box only protein 2

1

6

High-throughput

0.407

High

251343

CIDEA
Lipid transferase CIDEA

3

0

High-throughput

0.347

High

1193339

GLYR1
Cytokine-like nuclear factor N-PAC

3

0

High-throughput

0.347

High

1309601

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

3

0

High-throughput

0.345

High

1241885

DEN1B
DENN domain-containing protein 1B

3

0

High-throughput

0.342

High

244056

SUSD5
Sushi domain-containing protein 5

2

0

High-throughput

0.328

High

1238730

TECT3
Tectonic-3

2

0

High-throughput

0.318

High

282745

E2F6
Transcription factor E2F6

1

0

High-throughput

0.279

Low

946567

EVA1C
Protein eva-1 homolog C

1

0

High-throughput

0.279

Low

1123968

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.279

Low

1204672

BEX5
Protein BEX5

1

0

High-throughput

0.279

Low

1216472

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.279

Low

1218547

SPO16
Protein SPO16 homolog

1

0

High-throughput

0.279

Low

1248480

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

1

0

High-throughput

0.279

Low

1253603

CFA77
Cilia- and flagella-associated protein 77

1

0

High-throughput

0.279

Low

1309609

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.279

Low

1309619

CEP15
Centrosomal protein 15

1

0

High-throughput

0.269

Low

225634

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.249

Low

711652

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.249

Low

1124106

RCAN2
Calcipressin-2

1

0

High-throughput

0.249

Low

1309595

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

275055

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.232

Low

839584

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.232

Low

1098435

DNJC3
DnaJ homolog subfamily C member 3

1

0

High-throughput

0.232

Low

1309592

FA43A
Protein FAM43A

1

0

High-throughput

0.232

Low

1309596

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.232

Low

1309597

RETR2
Reticulophagy regulator 2

1

0

High-throughput

0.232

Low

1309617

NUDT9
ADP-ribose pyrophosphatase, mitochondrial

1

0

High-throughput

0.232

Low

1309637

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025