HitPredict

Interactor 1: SGS1 (P35187)
ATP-dependent helicase SGS1 (EC 5.6.2.4) (DNA 3'-5' helicase Sgs1) (Helicase TPS1)
Gene: SGS1

Interactor 2: MSH6 (Q03834)
DNA mismatch repair protein MSH6 (MutS protein homolog 6) (Postmeiotic segregation protein 3)
Gene: MSH6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	11805826, 26680658, 16429126
Identification Methods	tandem affinity purification, pull down, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016887 - ATP hydrolysis activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1447 Sc			1 1242
+	Sc
		639262 SGS1_YEAST (1-1447): 0: 1045: 100.00		MSH2_YEAST (314-1209): 0: 713: 20.59
+	Hs
		855440 BLM_HUMAN (339-1436): 1.51e-135: 455: 23.33		MSH6_HUMAN (60-1198): 0: 1045: 28.78
+	Hs
		801834 RECQ1_HUMAN (604-1247): 2.17e-122: 398: 35.02		MSH6_HUMAN (60-1198): 0: 1045: 28.78
+	Hs
		294565 RECQ4_HUMAN (656-1019): 1.23e-109: 378: 32.90		MSH6_HUMAN (60-1198): 0: 1045: 28.78
+	Hs
		794218 BLM_HUMAN (339-1436): 1.51e-135: 455: 23.33		MSH2_HUMAN (298-1193): 0: 838: 22.07
+	Hs
		794210 RECQ1_HUMAN (604-1247): 2.17e-122: 398: 35.02		MSH2_HUMAN (298-1193): 0: 838: 22.07
+	Hs
		294489 RECQ4_HUMAN (656-1019): 1.23e-109: 378: 32.90		MSH2_HUMAN (298-1193): 0: 838: 22.07
+	Sc
		415902 DED1_YEAST (606-1062): 9.11e-107: 354: 15.81		MSH1_YEAST (240-1164): 0: 693: 20.28