HitPredict

Interactor 1: SPT23 (P35210)
Protein SPT23
Gene: SPT23

Interactor 2: RSP5 (P39940)
E3 ubiquitin-protein ligase RSP5 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase RSP5) (Reverses SPT-phenotype protein 5)
Gene: RSP5

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	11733065, 11007476, 15466864, 17719829, 19597489, 11870222, 15933713, 17289586
Identification Methods	two hybrid, affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1082 Sc			1 809
+	Sc
		765285 MGA2_YEAST (90-1082): 0: 662: 36.39		RSP5_YEAST (1-809): 0: 825: 100.00
+	Hs
		808109 ANK3_HUMAN (342-926): 3.99e-71: 263: 8.94		NEDD4_HUMAN (102-807): 0: 668: 39.67
+	Hs
		1043731 ASPP2_HUMAN (314-795): 3.87e-52: 202: 14.29		ITCH_HUMAN (1-809): 0: 727: 34.62
+	Hs
		1336115 ANR50_HUMAN (596-984): 7.54e-52: 201: 13.03		SMUF1_HUMAN (4-809): 0: 701: 36.64
+	Hs
		125583 ANR44_HUMAN (567-932): 1.47e-57: 217: 14.25		WWP2_HUMAN (100-809): 0: 684: 40.81
+	Hs
		1164377 POTEE_HUMAN (671-1076): 1.37e-49: 193: 11.57		SMUF1_HUMAN (4-809): 0: 701: 36.64
+	Hs
		125441 ASPP2_HUMAN (314-795): 3.87e-52: 202: 14.29		WWP2_HUMAN (100-809): 0: 684: 40.81
+	Hs
		808118 ASPP2_HUMAN (314-795): 3.87e-52: 202: 14.29		NEDD4_HUMAN (102-807): 0: 668: 39.67
+	Hs
		808103 Q05BL1_HUMAN (314-795): 2.7e-51: 199: 14.29		NEDD4_HUMAN (102-807): 0: 668: 39.67
+	Hs
		125040 ANR17_HUMAN (685-935): 3.43e-28: 125: 11.58		WWP2_HUMAN (100-809): 0: 684: 40.81
+	Hs
		1336102 ANFY1_HUMAN (538-776): 3.01e-13: 76.5: 12.54		SMUF1_HUMAN (4-809): 0: 701: 36.64