HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.647

Property	Details
Experiments	27684187, 34079125, 17000760
Identification Methods	affinity chromatography technology, proximity labelling technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 781 Hs			1 669
+	Mm
		970164 CTNB1_MOUSE (1-781): 0: 624: 99.87		TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67
+	Hs
		716890 CTNB1_HUMAN (1-781): 0: 626: 100.00		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Mm
		970127 CTNB1_MOUSE (1-781): 0: 624: 99.87		SMCA4_MOUSE (18-526): 1.74e-30: 130: 12.69
+	Hs
		717033 CTNB1_HUMAN (1-781): 0: 626: 100.00		CGNL1_HUMAN (321-645): 5.23e-13: 74.7: 21.88
+	Rn
		100236 CTNB1_RAT (1-781): 0: 625: 99.74		F7F9U6_RAT (343-655): 1.61e-09: 63.5: 22.74
+	Hs
		148453 CTNB1_HUMAN (1-781): 0: 626: 100.00		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		716819 CTNB1_HUMAN (1-781): 0: 626: 100.00		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79
+	Hs
		148354 PLAK_HUMAN (8-752): 2.69e-158: 479: 67.42		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		853446 IMA1_HUMAN (237-675): 3.54e-66: 231: 18.54		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		846725 IMA1_HUMAN (237-675): 3.54e-66: 231: 18.54		SMCA2_HUMAN (18-531): 1.58e-34: 143: 13.60
+	Hs
		846726 IMA5_HUMAN (240-678): 2.52e-65: 228: 16.44		SMCA2_HUMAN (18-531): 1.58e-34: 143: 13.60
+	Hs
		131405 IMA4_HUMAN (220-681): 6.79e-68: 235: 15.25		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Hs
		846901 IMA1_HUMAN (237-675): 3.54e-66: 231: 18.54		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Hs
		853716 IMA5_HUMAN (240-678): 2.52e-65: 228: 16.44		Q9HBD4_HUMAN (18-526): 8.01e-31: 131: 13.06
+	Hs
		846902 IMA5_HUMAN (240-678): 2.52e-65: 228: 16.44		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Hs
		131340 IMA4_HUMAN (220-681): 6.79e-68: 235: 15.25		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		148559 IMA1_HUMAN (237-675): 3.54e-66: 231: 18.54		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36