HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 0.60 0.772

The method score is based on:

Property Details
Experiments 26506240, 20851351, 28018973, 30181396, 30923315, 30918250, 29789528, 33159601, 33482471, 16798748, 10228155, 10074433, 9990852, 17053147, 20531388, 18354482, 18851830, 22912335, 19150432, 21466614 and 35 others

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Identification Methods affinity chromatography technology, protein complementation assay, pull down, unspecified method, proximity labelling technology, enzymatic study, two hybrid, x-ray crystallography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000209 - protein polyubiquitination
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
and 2 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 781
Hs

1 605
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+ Dm
+ Ce
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024